{"id":4420,"date":"2021-06-01T04:00:42","date_gmt":"2021-05-31T20:00:42","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4420"},"modified":"2021-06-01T04:00:42","modified_gmt":"2021-05-31T20:00:42","slug":"discovery-of-28466-26-4-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4420","title":{"rendered":"Discovery of 28466-26-4"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 28466-26-4, name is 4-Aminopyrazole, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-Aminopyrazole<\/a><\/p>\n

Intermediate 25: 1 ,1-Dimethylethyl 6-[(1 \/-\/-pyrazol-4-ylamino)carbonyl1-3,4-dihydro- 2(1 HVisoalphauinolinecarboxylate; To a solution of 1 H-pyrazol-4-amine (1.87 g, 22.5 mmol), N-(3-dimethylaminopropyl)- N’-ethylcarbodiimide hydrochloride (5.18 g, 27 mmol), 1-hydroxybenzotriazole hydrate (3.65 g, 27 mmol) and triethylamine (6.3 ml_, 45 mmol) in DMF was added 2- {[(I J-dimethylethyOoxylcarbonylJ-i ^^^-tetrahydro-theta-isoquinolinecarboxylic acid (5.62 g, 20.3 mmol) and the reaction mixture was stirred at room temperature for 16 hours. The volatiles were removed under reduced pressure, the residue was dissolved in MeOH and potassium hydroxide (5.04 g, 90 mmol), water (100 ml.) was added and the mixture was heated at 500C for 15 min. The MeOH was evaporated under reduced pressure and the solid which crystallized was filtered and recrystallized from acetonitrile to give the title compound as a solid (3.7 g, 48%). LC\/MS: m\/z 341 (M-H)+, Rt: 2.80 min.<\/p>\n

According to the analysis of related databases, 28466-26-4, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008\/74824; (2008); A2;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 28466-26-4, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[144,131],"tags":[145],"class_list":["post-4420","post","type-post","status-publish","format-standard","hentry","category-28466-26-4","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nDiscovery of<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 28466-26-4, name is 4-Aminopyrazole, This compound has unique chemical properties. 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