{"id":4383,"date":"2021-05-31T04:37:49","date_gmt":"2021-05-30T20:37:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4383"},"modified":"2021-05-31T04:37:49","modified_gmt":"2021-05-30T20:37:49","slug":"simple-exploration-of-c4h5in2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4383","title":{"rendered":"Simple exploration of C4H5IN2"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39806-90-1, Formula: C4H5IN2<\/a><\/p>\n

Step 1: Prepartion of tert-but 4-(l-methyI-lH-pyrazoI-4-yl)-3-oxopiperazine~l- carboxylate: tot-Butyl 3-oxopiperazine-l-carbox late (0.164 g, 0.819 mmol) was suspended in isopropanol (3 mL) under an atmosphere of nitrogen and treated with l-methyl-4-iodo-lH- pyrazole (0.204 g, 0.983 mmol, 1.20 equiv), ethylene glycol (0.051 g, 0.82 mmol, 1.0 equiv). copper iodide (0.03 g, 0.16 mmol, 0.20 equiv), and potassium phosphate (0.695 g, 3.28 mmol, 4.00 equiv), and placed into a preheated oil bath at 100 C for 8 hours. The mixture was cooled to ambient temperature, concentrated in vacuo and the residue was dissolved in dichloromethane, washed with water, dried with sodium sulfate, filtered, and concentrated in vacuo. The residue was purified by silica gel chromatography (100:0 to 0: 100 hexanes : ethyl acetate), providing the titled compound.<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n

Reference:
Patent; MERCK SHARP & DOHME CORP.; BESHORE, Douglas, C.; KUDUK, Scott, D.; WO2011\/137049; (2011); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[162,131],"tags":[127],"class_list":["post-4383","post","type-post","status-publish","format-standard","hentry","category-39806-90-1","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nSimple exploration of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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