{"id":4381,"date":"2021-05-31T04:37:49","date_gmt":"2021-05-30T20:37:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4381"},"modified":"2021-05-31T04:37:49","modified_gmt":"2021-05-30T20:37:49","slug":"research-on-new-synthetic-routes-about-5334-40-7-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4381","title":{"rendered":"Research on new synthetic routes about 5334-40-7"},"content":{"rendered":"

Some common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, molecular formula is C4H3N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 5334-40-7<\/a><\/p>\n

A mixture of 4-nitro-3-pyrazolecarboxylic acid (4.98 g, 31.7 mmol), trans 4-aminocyclohexanol (3.65 g, 31.7 mmol), EDAC (6.68 g, 34.8 mmol) and HOBt (4.7 g, 34.8 mmol) in DMF (120 ml) was stirred at ambient temperature for 16 hours. The mixture was reduced in vacuo, the residue taken up in CH2CI2 and washed successively with 5percent citric acid, saturated aqueous sodium bicarbonate, water and brine. The product was found to be mainly in the citric acid wash, which was basified and extracted with EtOAc. The organic layer was dried over MgSO4, filtered and evaporated to give a white solid, which was triturated with CHCI3 to give 1.95 g of 4-nitro-1H-pyrazole-3-carboxylic acid 4-hydroxy-cyclohexylamide. (LC\/MS: Rt 1.62, [M+H]+255).<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5334-40-7, its application will become more common.<\/p>\n

Reference:
Patent; ASTEX THERAPEUTICS LIMITED; WO2006\/77424; (2006); A1;; ; Patent; ASTEX THERAPEUTICS LIMITED; WO2006\/77425; (2006); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5334-40-7, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[153,131],"tags":[126],"class_list":["post-4381","post","type-post","status-publish","format-standard","hentry","category-5334-40-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nResearch on new synthetic routes about<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, molecular formula is C4H3N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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