{"id":4370,"date":"2021-05-31T04:37:49","date_gmt":"2021-05-30T20:37:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4370"},"modified":"2021-05-31T04:37:49","modified_gmt":"2021-05-30T20:37:49","slug":"some-tips-on-95162-14-4-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4370","title":{"rendered":"Some tips on 95162-14-4"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 95162-14-4, name is 4-Bromo-1-tritylpyrazole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 4-Bromo-1-tritylpyrazole<\/a><\/p>\n

To a 500 mL Schenk flask backfilled with N2was added 4-bromo-1-trityl-1H-pyrazole(10.0 g, 25.7 mmol) and dry THF (250 mL). The resulting suspension was cooledto -78 C under stirring. 1.6 M n-butyl lithium (20.0 mL, 32.0 mmol, 1.2equiv.) was then added dropwise, and the solution was left to stir for 30minutes before adding triisopropyl borate (7.4 mL, 32.0 mmol, 1.2 equiv.)dropwise. The resulting solution was stirred at 1 hour at -78 C and allowed toreach room temperature over 1 hour. Pinacol (3.9 g, 33.4 mmol, 1.3 equiv.) wasadded under stirring, and the solution was stirred for 30 minutes before addingglacial acetic acid (1.6 mL, 28.3 mmol, 1.1 equiv.). The suspension was stirredfor a further 30 minutes before removing the solvent in vacuo to yield awhite solid. Recrystallization was achieved by triturating the crude compoundin DCM (3 mL) and methanol (200 mL) over 1 hour. The resulting solid wascollected by filtration, washed with methanol and dried overnight at 50 C toyield 1-trityl-1H-pyrazol-4-ylboronatepinacol ester (9.1 g, 20.9 mmol, 81.4%) as a white solid. 1H NMR (500 MHz, CD2Cl2) delta = 1.28(s, 12H), 7.12 – 7.14 (m, 6H), 7.30 – 7.33 (m, 9H), 7.63 (d, J = 0.9 Hz, 1H),7.81 (d, J = 0.9 Hz,). 13CNMR (125 MHz, CD2Cl2) delta = 25.17, 79.22, 83.82, 128.25,130.72, 139.35, 143.82, 145.83. HRMS(ESI) Calcd for C28H29BN2O2 [M+H]: 437.239983;Found: 437.240521.<\/p>\n

According to the analysis of related databases, 95162-14-4, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Article; Kershaw Cook, Laurence J.; Kearsey, Rachel; Lamb, Jessica V.; Pace, Edward J.; Gould, Jamie A.; Tetrahedron Letters; vol. 57; 8; (2016); p. 895 – 898;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 95162-14-4, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[252,131],"tags":[167],"class_list":["post-4370","post","type-post","status-publish","format-standard","hentry","category-95162-14-4","category-pyrazoles-derivatives","tag-m-w300-400"],"yoast_head":"\nSome tips on<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 95162-14-4, name is 4-Bromo-1-tritylpyrazole, This compound has unique chemical properties. 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