{"id":4360,"date":"2021-05-28T03:58:15","date_gmt":"2021-05-27T19:58:15","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4360"},"modified":"2021-05-28T03:58:15","modified_gmt":"2021-05-27T19:58:15","slug":"a-new-synthetic-route-of-20583-33-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4360","title":{"rendered":"A new synthetic route of 20583-33-9"},"content":{"rendered":"

Application of 20583-33-9<\/a>, These common heterocyclic compound, 20583-33-9, name is 1-(1H-Pyrazol-3-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

Pyrazole viii (30 g, 0.27 mol) and cesium carbonate (98 g, 0.30 mol) are dissolved in dimethyiformamide (DMF) (300 niL). 2-Bromopropane (30 mL, 0.32 mol) is added dropwise and the mixture is stirred for 12 hours. The mixture is poured onto water (1 L) and extracted into ethyl acetate. The organic layer is washed with brine, dried over sodium sulfate, and (0154) concentrated to give substituted pyrazole ix (22 g, 0.14 mol) as a pale yellow liquid winch is used without further purification.<\/p>\n

Statistics shows that 1-(1H-Pyrazol-3-yl)ethanone is playing an increasingly important role. we look forward to future research findings about 20583-33-9.<\/p>\n

Reference:
Patent; CLAVIUS PHARMACEUTICALS, LLC; SAWYER, J. Scott; (132 pag.)WO2020\/41562; (2020); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

Statistics shows that 1-(1H-Pyrazol-3-yl)ethanone is playing an increasingly important role. we look forward to future research findings about 20583-33-9.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[363,131],"tags":[126],"class_list":["post-4360","post","type-post","status-publish","format-standard","hentry","category-20583-33-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nA new synthetic route of<\/title>\n<meta name=\"description\" content=\"Application of 20583-33-9, These common heterocyclic compound, 20583-33-9, name is 1-(1H-Pyrazol-3-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4360\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new synthetic route of\" \/>\n<meta property=\"og:description\" content=\"Application of 20583-33-9, These common heterocyclic compound, 20583-33-9, name is 1-(1H-Pyrazol-3-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4360\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-27T19:58:15+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4360\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4360\",\"name\":\"A new synthetic route of\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-05-27T19:58:15+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Application of 20583-33-9, These common heterocyclic compound, 20583-33-9, name is 1-(1H-Pyrazol-3-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4360#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=4360\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4360#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"A new synthetic route of 20583-33-9\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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