{"id":4335,"date":"2021-05-28T03:57:26","date_gmt":"2021-05-27T19:57:26","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4335"},"modified":"2021-05-28T03:57:26","modified_gmt":"2021-05-27T19:57:26","slug":"new-downstream-synthetic-route-of-288148-34-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4335","title":{"rendered":"New downstream synthetic route of 288148-34-5"},"content":{"rendered":"

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. name: 1-Methyl-1H-pyrazole-4-sulfonyl chloride<\/a><\/p>\n

Add triethylamine (3.403 mL, 24.414 mmol) to a stirring solution of {2-[4-(2- chloro-pyridin-3-yl)-piperazin-l-yl]-ethyl}-methyl-amine hydrochloride salt (2.000 g, 6.103 mmol) in dichloromethane (100 mL). Add 1 -methyl- lH-pyrazole-4-sulfonyl chloride (1.102 g, 6.103 mmol) at room temperature. Stir at room temperature for 30 min. Dilute with dichloromethane and saturated aqueous sodium bicarbonate. Separate phases and extract the aqueous phase with dichloromethane. Combine the organic phases, dry over sodium sulfate, filter, and concentrate. Purify the resulting material by silica gel chromatography eluting with hexanes: acetone 1 : 1 to afford the title preparation (1.600 g, 66% yield). MS ES: m\/z = 399 [M+H]+.<\/p>\n

The synthetic route of 288148-34-5 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; ELI LILLY AND COMPANY; WO2009\/29439; (2009); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 288148-34-5 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[224,131],"tags":[126],"class_list":["post-4335","post","type-post","status-publish","format-standard","hentry","category-288148-34-5","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nNew downstream synthetic route of<\/title>\n<meta name=\"description\" content=\"In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. name: 1-Methyl-1H-pyrazole-4-sulfonyl chloride\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4335\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New downstream synthetic route of\" \/>\n<meta property=\"og:description\" content=\"In the next few decades, the world population will flourish. 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