{"id":4306,"date":"2021-05-27T03:56:11","date_gmt":"2021-05-26T19:56:11","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4306"},"modified":"2021-05-27T03:56:11","modified_gmt":"2021-05-26T19:56:11","slug":"some-tips-on-1904-31-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4306","title":{"rendered":"Some tips on 1904-31-0"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., name: 1-Methyl-1H-pyrazol-3-amine<\/a><\/p>\n

Example 80; 4-Benzyloxy-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide; To a solution of 4-benzyloxy-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid (77b) (6.98 g, 23.40 mmol) in CH2Cl2 (100 mL) was added thionyl chloride (2.04 mL, 28.1 mmol), followed by 10 drops of DMF. The mixture was refluxed for 2 h, then concentrated and dried under vacuum. The residue was dissolved in CH2Cl2 (100 mL), and 3-amino-1-methyl-pyrazole (2.73 g, 28.1 mmol) was added at 0\u00b0 C., followed by triethylamine (6.52 ml, 46.80 mmol). The mixture was stirred at 0\u00b0 C. to room temperature for 1 hr. The reaction was quenched with H2O, extracted with 3.x.CH2Cl2. The combined organic layers were dried over Na2SO4, concentrated and purified by flash column chromatography with 1-3percent MeOH in CHCl3 to give a white solid (5.31 g, 60percent yield). 1H NMR (400 MHz, CDCl3) delta 8.43 (s, 1H) 7.29-7.50 (m, 6H) 7.09 (d, J=1.01 Hz, 1H) 6.84 (dd, J=8.08, 1.77 Hz, 2H) 5.14 (s, 2H) 3.83 (s, 3H) 2.95-3.06 (m, 2H) 1.50 (s, 6H); LCMS for C22H23N3O3 m\/z 378.20 (M+H+).<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n

Reference:
Patent; Pfizer Inc.; US2008\/280875; (2008); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[219,131],"tags":[145],"class_list":["post-4306","post","type-post","status-publish","format-standard","hentry","category-1904-31-0","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nSome tips on<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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