{"id":4294,"date":"2021-05-26T05:00:53","date_gmt":"2021-05-25T21:00:53","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4294"},"modified":"2021-05-26T05:00:53","modified_gmt":"2021-05-25T21:00:53","slug":"the-origin-of-a-common-compound-about-146941-72-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4294","title":{"rendered":"The origin of a common compound about 146941-72-2"},"content":{"rendered":"<p>146941-72-2, name is 4-Bromo-1-methyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. <a href=\"https:\/\/www.ambeed.com\/products\/146941-72-2.html\">Formula: C4H6BrN3<\/a><\/p>\n<p>General procedure: A soln. of amine BB-34 (1 eq) and aldehyde or ketone BB-12 (1.05 to 1.1 eq) in MeOH (2 to 4 mL\/mmol) was stirred for 1 h at RT. NaBI-U (1.6 to 2 eq) was added portionwise at 0C and the rxn mixture was stirred at a given temperature for a given time (see Table 52). It was quenched with H2O at 0C and extracted with EtOAc. The combined org. phases were washed with brine, dried over MgSCh and concentrated in vacuo. When necessary, the crude was purified by CC using EtOAc\/MeOH<\/p>\n<p>The synthetic route of 146941-72-2 has been constantly updated, and we look forward to future research findings.<\/p>\n<p>Reference:<br \/><a href=\"http:\/\/v3.espacenet.com\/textdoc?DB=EPODOC&#038;IDX=WO2019137927&#038;F=0\">Patent; IDORSIA PHARMACEUTICALS LTD; FROIDEVAUX, Sylvie; HUBLER, Francis; MURPHY, Mark; RENNEBERG, Dorte; STAMM, Simon; (266 pag.)WO2019\/137927; (2019); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The synthetic route of 146941-72-2 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[344,131],"tags":[126],"class_list":["post-4294","post","type-post","status-publish","format-standard","hentry","category-146941-72-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The origin of a common compound about<\/title>\n<meta name=\"description\" content=\"146941-72-2, name is 4-Bromo-1-methyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. 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