{"id":4268,"date":"2021-05-25T04:08:40","date_gmt":"2021-05-24T20:08:40","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4268"},"modified":"2021-05-25T04:08:40","modified_gmt":"2021-05-24T20:08:40","slug":"the-important-role-of-920006-32-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4268","title":{"rendered":"The important role of 920006-32-2"},"content":{"rendered":"

920006-32-2, name is 1-Isopropylpyrazole-5-carboxylic Acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 1-Isopropylpyrazole-5-carboxylic Acid<\/a><\/p>\n

DIPEA (94 pL, 0.57 mmol) was added to a stirred solution of Intermediate 56 (70 mg, 0.19 mmol), 1 -(propan-2-yl)- 17\/-pyrazolc-5-carboxylic acid (44 mg, 0.28 mmol) and HATU (112 mg, 0.29 mmol) in DCM (2.5 mL) at r.t. The reaction mixture was stirred at r.t. for 18 h, then diluted with water (5 mL) and extracted with DCM (3 x 15 mL). The combined organic phases were separated using a hydrophobic PTLE frit, and concentrated in vacuo. The residue was purified by flash column chromatography on silica, using a gradient of fc\/7-butyl methyl ether in heptane (0-80%), to afford the title compound (61 mg, 65%) as a white solid. 5H (250 MHz, DMSO-de) 10.12 (s, 1H), 8.45 (d, J8.2 Hz,1H), 7.70-7.66 (m, 1H), 7.50 (d, 1.9 Hz, 1H), 7.43-7.33 (m, 2H), 7.12 (d, J5.6 Hz, 1H), 6.95 (d, 2.0 Hz, 1H), 6.81 (d, J5.7 Hz, 1H), 5.44-5.34 (m, 1H), 4.37 (t, j 8.5 Hz, 1H), 3.99-3.90 (m, 2H), 3.77-3.67 (m, 2H), 2.11-2.01 (m, 2H), 1.91-1.75 (m, 2H), 1.74-1.65(m, 2H), 1.63-1.56 (m, 1H), l.37 (d, 6.6 Hz, 3H), 1.34 (d, J6.6 Hz, 3H), 1.32-1.26 (m, 1H), 1.25-1.18 (m, 1H), 1.16-1.10 (m, 2H), 1.10-1.01 (m, 1H), 0.92-0.81 (m, 5H). uPLC- MS (method 1): MH+ m\/z 491, RT 4.06 minutes.<\/p>\n

The synthetic route of 920006-32-2 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; UCB BIOPHARMA SRL; BRACE, Gareth Neil; BROOKINGS, Daniel Christopher; FOULKES, Gregory; LECOMTE, Fabien Claude; (0 pag.)WO2020\/11731; (2020); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 920006-32-2 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[615,131],"tags":[126],"class_list":["post-4268","post","type-post","status-publish","format-standard","hentry","category-920006-32-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of<\/title>\n<meta name=\"description\" content=\"920006-32-2, name is 1-Isopropylpyrazole-5-carboxylic Acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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