{"id":4251,"date":"2021-05-25T04:07:47","date_gmt":"2021-05-24T20:07:47","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4251"},"modified":"2021-05-25T04:07:47","modified_gmt":"2021-05-24T20:07:47","slug":"extracurricular-laboratory-synthetic-route-of-1904-24-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4251","title":{"rendered":"Extracurricular laboratory: Synthetic route of 1904-24-1"},"content":{"rendered":"

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1904-24-1, name is 3-Amino-5-ethylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C5H9N3<\/a><\/p>\n

Method 65; 4- (5-Ethvl-lH-pyrazol-3-vlamino)-2-chloropyrimidine A mixture of 2, 4-dichloropyrimidine (2.97g, 20mmol), 5-amino-3-ethyl-1H-pyrazole (2.44g, 22mmol) and N, N-diisopropylethylamine (3. 8ml, 22mmol) in dry THF (75ml) was heated at 60C for 18 hours. The volatiles were removed by evaporation, and the residue was triturated with a mixture of DCM and water. The solid product was collected by filtration, washed with water and ether, and dried to give the title compound (1.55g, 35%) as a colourless crystalline solid. NMR (DMSO): 1.20 (t, 3H), 2.60 (q, 2H), 6.06 (s, 1H), 7.15 (s, 1H), 8.10 (d, 1H), 9.80 (s, 1H), 11.83 (br s, 1H); m\/z 224 [MH] +.<\/p>\n

The synthetic route of 1904-24-1 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005\/40159; (2005); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 1904-24-1 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[644,131],"tags":[126],"class_list":["post-4251","post","type-post","status-publish","format-standard","hentry","category-1904-24-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nExtracurricular laboratory: Synthetic route of<\/title>\n<meta name=\"description\" content=\"In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1904-24-1, name is 3-Amino-5-ethylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. 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