{"id":4235,"date":"2021-05-24T04:29:49","date_gmt":"2021-05-23T20:29:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4235"},"modified":"2021-05-24T04:29:49","modified_gmt":"2021-05-23T20:29:49","slug":"continuously-updated-synthesis-method-about-c8h7n3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4235","title":{"rendered":"Continuously updated synthesis method about C8H7N3"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25700-12-3 as follows. Safety of 3-(1H-Pyrazol-1-yl)pyridine<\/a><\/p>\n

3-Pyrazol-1-yl-pyridine (2 g, 0.032 mol) was dissolved in concentrated H2SO4 (32 mL 0.598 mmol.) and cooled to -5 C. using an ice bath. To the reaction mass, a 1:1 mixture of concentrated HNO3 (30 mL, 0.673 mmol) and concentrated H2SO4 (30 ml, 15 Vol.) was added dropwise over a period of 30 min Cooling was discontinued and the reaction mixture was stirred at room temperature overnight. After the reaction was complete, the mixture was poured over crushed ice and neutralized with saturated NaHCO3, filtered, washed with water and dried to furnish the nitro pyrazole as pale yellow solid (1.8 g, 68%): 1H NMR (400 MHz, DMSO-d6) delta 9.03 (d, J=2.8 Hz, 1H); 8.70 (dd, J=4.8, 1.6 Hz, 1H), 8.69 (s, 1H), 8.33 (s, 1H), 8.11-8.08 (m, 1H), 7.51 (dd, J=8.4, 4.8 Hz, 1H); MS (m\/z) 191 [M+1].<\/p>\n

According to the analysis of related databases, 25700-12-3, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; Dow Agrosciences LLC; Niyaz, Noormohamed M.; Garizi, Negar; Zhang, Yu; Trullinger, Tony K.; Hunter, Ricky; Buysse, Ann M.; Kubota, Asako; LePlae, Jr., Paul Renee; Knueppel, Daniel; Lowe, Christian T.; Pernich, Dan; Demeter, David A.; Johnson, Timothy C.; US2013\/109566; (2013); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 25700-12-3, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[606,131],"tags":[126],"class_list":["post-4235","post","type-post","status-publish","format-standard","hentry","category-25700-12-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nContinuously updated synthesis method about<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25700-12-3 as follows. 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