{"id":4233,"date":"2021-05-24T04:29:49","date_gmt":"2021-05-23T20:29:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4233"},"modified":"2021-05-24T04:29:49","modified_gmt":"2021-05-23T20:29:49","slug":"simple-exploration-of-59074-26-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4233","title":{"rendered":"Simple exploration of 59074-26-9"},"content":{"rendered":"

Synthetic Route of 59074-26-9<\/a>,Some common heterocyclic compound, 59074-26-9, name is 3-(4-Chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazole, molecular formula is C15H13ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

Part A: A stirred solution of 3-(4-chlorophenyl)-4,5-dihydro-4-phenyl-1H-pyrazole (5.00 gram, 19.5 mmol) and N-(tert-butoxycarbonyl)aziridine (2.00 gram, 14.0 mmol) in toluene (100 ml) was heated at reflux temperature for 16 hours. After concentration in vacuo the residue was purified by flash chromatography (petroleum ether\/diethyl ether=3\/1 (v\/v)), followed by petroleum ether\/diethyl ether=1\/1 (v\/v)). After concentration in vacuo the remaining oily residue was crystallized from diisopropyl ether to afford 1-[2-((tert-butoxycarbonyl)amino)ethyl]-3-(4-chlorophenyl)-4,5-dihydro-4-phenyl-1H-pyrazole (1.91 gram, 34%). Repeated crystallisations from the mother liquor afforded an additional amount of crystalline 1-[2-((tert-butoxycarbonyl)amino)ethyl]-3-(4-chlorophenyl)-4,5-dihydro-4-phenyl-1H-pyrazole (1.19 gram).<\/p>\n

The synthetic route of 59074-26-9 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; Solvay Pharmaceuticals B.V.; US2001\/53788; (2001); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 59074-26-9 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[700,131],"tags":[127],"class_list":["post-4233","post","type-post","status-publish","format-standard","hentry","category-59074-26-9","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nSimple exploration of<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 59074-26-9,Some common heterocyclic compound, 59074-26-9, name is 3-(4-Chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazole, molecular formula is C15H13ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4233\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Simple exploration of\" \/>\n<meta property=\"og:description\" content=\"Synthetic Route of 59074-26-9,Some common heterocyclic compound, 59074-26-9, name is 3-(4-Chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazole, molecular formula is C15H13ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4233\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-23T20:29:49+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4233\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4233\",\"name\":\"Simple exploration of\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-05-23T20:29:49+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Synthetic Route of 59074-26-9,Some common heterocyclic compound, 59074-26-9, name is 3-(4-Chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazole, molecular formula is C15H13ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4233#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=4233\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4233#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Simple exploration of 59074-26-9\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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