{"id":4226,"date":"2021-05-24T04:28:49","date_gmt":"2021-05-23T20:28:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4226"},"modified":"2021-05-24T04:28:49","modified_gmt":"2021-05-23T20:28:49","slug":"share-a-compound-tert-butyl-1h-pyrazole-4-carboxylate","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4226","title":{"rendered":"Share a compound : tert-Butyl 1H-pyrazole-4-carboxylate"},"content":{"rendered":"<p>Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 611239-23-7, name is tert-Butyl 1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., <a href=\"https:\/\/www.ambeed.com\/products\/611239-23-7.html\">Application In Synthesis of  tert-Butyl 1H-pyrazole-4-carboxylate<\/a><\/p>\n<p>To a solution of N-benzhydryl-6-chloro-4-methoxynicotinamide (200 mg, 0.6 mmol) in dioxane (16 mL) were added tert-butyl 1H-pyrazole-4- carboxylate (100 mg, 0.6 mmol), CuT (56 mg, 0.3 mmol), Cs2CO3 (550 mg, 1.7 mmol) and N,N-dimethylglycine (64 mg, 0.6 mmol). The mixture was stirred at 120C overnight. When TLC showed the reaction completed, the mixture was filtered. The filtrate was diluted with water (20 mL) and extractedwith EtOAc (40 mL). The organic layer was washed with brine (20 mL), dried over sodium sulfate and concentrated under vacuum. The residue was purified by prep. TLC (EtOAc \/PE=3:1) to afford tert-butyl 1 -(5 -(benzhydrylcarbamoyl)-4- hydroxypyridin-2-yl)- 1 H-pyrazole-4- carboxylate. ?H NIVIR (CDC13,400 IVIHz) 12.87 (s, 1H), 8.88 (s, 1H), 8.50 (s, 1H), 8.02 (s, 1H), 7.55-7.50 (m, 1H), 7.42-7.27 (m, 11H), 6.41 (d, J= 7.3 Hz, 1H), 1.57 (s, 9H). LC\/IVIS (m\/z):471 (M+H).<\/p>\n<p>The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n<p>Reference:<br \/><a href=\"http:\/\/v3.espacenet.com\/textdoc?DB=EPODOC&#038;IDX=WO2016054806&#038;F=0\">Patent; MERCK SHARP &amp; DOHME CORP.; UJJAINWALLA, Fez; TAN, John Qiang; DANG, Qun; SINZ, Christopher J.; WANG, Ming; CHEN, Yili; CAI, Jiaqiang; DU, Xiaoxing; (41 pag.)WO2016\/54806; (2016); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[668,131],"tags":[126],"class_list":["post-4226","post","type-post","status-publish","format-standard","hentry","category-611239-23-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Share a compound :<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 611239-23-7, name is tert-Butyl 1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., Application In Synthesis of tert-Butyl 1H-pyrazole-4-carboxylate\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4226\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Share a compound :\" \/>\n<meta property=\"og:description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 611239-23-7, name is tert-Butyl 1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., Application In Synthesis of tert-Butyl 1H-pyrazole-4-carboxylate\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4226\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-23T20:28:49+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4226\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4226\",\"name\":\"Share a compound :\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-05-23T20:28:49+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 611239-23-7, name is tert-Butyl 1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., Application In Synthesis of tert-Butyl 1H-pyrazole-4-carboxylate\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4226#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=4226\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4226#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Share a compound : tert-Butyl 1H-pyrazole-4-carboxylate\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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