{"id":4215,"date":"2021-05-24T04:28:49","date_gmt":"2021-05-23T20:28:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4215"},"modified":"2021-05-24T04:28:49","modified_gmt":"2021-05-23T20:28:49","slug":"continuously-updated-synthesis-method-about-5-methyl-1h-pyrazole-3-carbaldehyde","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4215","title":{"rendered":"Continuously updated synthesis method about 5-Methyl-1H-pyrazole-3-carbaldehyde"},"content":{"rendered":"

Reference of 3273-44-7<\/a>, The chemical industry reduces the impact on the environment during synthesis 3273-44-7, name is 5-Methyl-1H-pyrazole-3-carbaldehyde, I believe this compound will play a more active role in future production and life.<\/p>\n

A mixture of 5,6-diamino-l-(2-methoxy-ethyl)-3,3-dimethyl-l,3-dihydro-indol-2- one (210mg, 0.842mmol), 5-methyl-lH-pyrazole-3-carbaldehyde (prepared according to Tetrahedron 1995, 51(16), 4779-800; 93mg, 0.842mmol) and sulfur (29.7mg, 0.926mmol) in N,N-dimethylformamide (DMF) (6ml) was heated at1600C for 65 minutes. After cooling to room temperature the reaction mixture was poured into water (40ml). After stirring for 60 minutes at 00C the precipitate was filtered off, washed with water and dissolved in ethyl acetate. The aqueous mother liquid was extracted with ethyl acetate and the combined organic phases were dried over magnesium sulfate. The solvent was removed under reduced pressure und the residue dried in vacuo to yield 186mg 5-(2-methoxy-ethyl)-7,7-dimethyl-2-(5- methyl-lH-pyrazol-3-yl)-5,7-dihydro-3H-imidazo[4,5-f] indol-6-one (65%). MS: M = 340.2 (ESI+) 1H-NMR (400 MHz, Dn-DMSO): delta (ppm) = 1.31 (s, 6H), 2.31 (s, 3H), 3.25 (s, 3H), 3.59 (t, 2H), 3.89 (t, 2H), 6.56 (s, IH), 7.03 and 7.25 (bm, IH), 7.35 and 7.55 (bm, IH), 12.59 (m, IH), 12.88 (m, IH)<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methyl-1H-pyrazole-3-carbaldehyde, other downstream synthetic routes, hurry up and to see.<\/p>\n

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2007\/68465; (2007); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methyl-1H-pyrazole-3-carbaldehyde, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[640,131],"tags":[126],"class_list":["post-4215","post","type-post","status-publish","format-standard","hentry","category-3273-44-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nContinuously updated synthesis method about<\/title>\n<meta name=\"description\" content=\"Reference of 3273-44-7, The chemical industry reduces the impact on the environment during synthesis 3273-44-7, name is 5-Methyl-1H-pyrazole-3-carbaldehyde, I believe this compound will play a more active role in future production and life.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4215\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Continuously updated synthesis method about\" \/>\n<meta property=\"og:description\" content=\"Reference of 3273-44-7, The chemical industry reduces the impact on the environment during synthesis 3273-44-7, name is 5-Methyl-1H-pyrazole-3-carbaldehyde, I believe this compound will play a more active role in future production and life.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4215\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-23T20:28:49+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4215\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4215\",\"name\":\"Continuously updated synthesis method about\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-05-23T20:28:49+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Reference of 3273-44-7, The chemical industry reduces the impact on the environment during synthesis 3273-44-7, name is 5-Methyl-1H-pyrazole-3-carbaldehyde, I believe this compound will play a more active role in future production and life.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4215#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=4215\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4215#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Continuously updated synthesis method about 5-Methyl-1H-pyrazole-3-carbaldehyde\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Continuously updated synthesis method about","description":"Reference of 3273-44-7, The chemical industry reduces the impact on the environment during synthesis 3273-44-7, name is 5-Methyl-1H-pyrazole-3-carbaldehyde, I believe this compound will play a more active role in future production and life.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=4215","og_locale":"en_US","og_type":"article","og_title":"Continuously updated synthesis method about","og_description":"Reference of 3273-44-7, The chemical industry reduces the impact on the environment during synthesis 3273-44-7, name is 5-Methyl-1H-pyrazole-3-carbaldehyde, I believe this compound will play a more active role in future production and life.","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=4215","og_site_name":"pyrazoles-derivatives","article_published_time":"2021-05-23T20:28:49+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=4215","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=4215","name":"Continuously updated synthesis method about","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2021-05-23T20:28:49+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Reference of 3273-44-7, The chemical industry reduces the impact on the environment during synthesis 3273-44-7, name is 5-Methyl-1H-pyrazole-3-carbaldehyde, I believe this compound will play a more active role in future production and life.","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=4215#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=4215"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=4215#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Continuously updated synthesis method about 5-Methyl-1H-pyrazole-3-carbaldehyde"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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