{"id":4214,"date":"2021-05-24T04:28:49","date_gmt":"2021-05-23T20:28:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4214"},"modified":"2021-05-24T04:28:49","modified_gmt":"2021-05-23T20:28:49","slug":"introduction-of-a-new-synthetic-route-about-1001020-13-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4214","title":{"rendered":"Introduction of a new synthetic route about 1001020-13-8"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 1001020-13-8, name is (3-Trifluoromethyl-1H-pyrazol-4-yl)methanol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1001020-13-8, category: pyrazoles-derivatives<\/a><\/p>\n

(3-(Trifluoromethyl)-1H-pyrazol-4-yl)methanol (54.00 g, 0.325 mol) was suspended in toluene (2 L). MnO2 (113.00 g, 1.30 mol) and 4 molecular sieve powder (54.00 g) were added. The reaction mixture was stirred at reflux under nitrogen with a Dean-Stark trap for 5.5 h. The resulting mixture was filtered hot and the cake allowed to cool before washing with 1:1 DCM:MeOH solution (3\u00d7500 mL). The combined filtrates were concentrated in vacuo to give the desired product (54.00 g, 0.329 mol, 100%).1H NMR (400 MHz, DMSO): delta 8.72 (s, 1H), 9.91 (s, 1H)<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n

Reference:
Patent; N.V. Organon; US2009\/131455; (2009); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[604,131],"tags":[126],"class_list":["post-4214","post","type-post","status-publish","format-standard","hentry","category-1001020-13-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nIntroduction of a new synthetic route about<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 1001020-13-8, name is (3-Trifluoromethyl-1H-pyrazol-4-yl)methanol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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