{"id":4203,"date":"2021-05-21T03:40:09","date_gmt":"2021-05-20T19:40:09","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4203"},"modified":"2021-05-21T03:40:09","modified_gmt":"2021-05-20T19:40:09","slug":"the-important-role-of-4-chloromethyl-1-2-fluorophenyl-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4203","title":{"rendered":"The important role of 4-(Chloromethyl)-1-(2-fluorophenyl)-1H-pyrazole"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/35715-72-1.html\">Reference of 35715-72-1<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35715-72-1 name is 4-(Chloromethyl)-1-(2-fluorophenyl)-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n<p>To a mixture of 237 4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (Preparation 71, 20 g, 71.7 mmol) in 21 DMF (200 mL) was added 116 K2CO3 (49.5 g, 358.5 mmol) and the mixture stirred for 10 min at rt before 239 4-(chloromethyl)-1-(2-fluorophenyl)-1H-pyrazole (Preparation 98, 20 g, 95.2 mmol) was added. The resulting mixture was stirred at 60 C. for 6 hr, filtered and concentrated under reduced pressure to give a crude product which was washed with EtOAc and water to afford the 197 title compound (20 g, 62.5%) as a yellow solid. 1HNMR (400 MHz, CDCl3): 5.41 (s, 2H), 7.20-7.32 (m, 3H), 7.42 (s, 1H), 7.72 (s, 1H), 7.84-7.87 (m, 1H), 8.05 (d, 1H), 8.68 (s, 1H). LCMS m\/z=453.9 [MH]+<\/p>\n<p>At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(Chloromethyl)-1-(2-fluorophenyl)-1H-pyrazole, and friends who are interested can also refer to it.<\/p>\n<p>Reference:<br \/><a href=\"http:\/\/v3.espacenet.com\/textdoc?DB=EPODOC&#038;IDX=US2018141954&#038;F=0\">Patent; CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC.; Strohbach, Joseph Walter; Limburg, David Christopher; Mathias, John Paul; Thorarensen, Atli; Denny, Rajiah Aldrin; Zapf, Christoph Wolfgang; Elbaum, Daniel; Gavrin, Lori Krim; Efremov, Ivan Viktorovich; (159 pag.)US2018\/141954; (2018); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(Chloromethyl)-1-(2-fluorophenyl)-1H-pyrazole, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[693,131],"tags":[127],"class_list":["post-4203","post","type-post","status-publish","format-standard","hentry","category-35715-72-1","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The important role of<\/title>\n<meta name=\"description\" content=\"Reference of 35715-72-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35715-72-1 name is 4-(Chloromethyl)-1-(2-fluorophenyl)-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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The downstream synthesis method of this compound is introduced below.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=4203","og_locale":"en_US","og_type":"article","og_title":"The important role of","og_description":"Reference of 35715-72-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35715-72-1 name is 4-(Chloromethyl)-1-(2-fluorophenyl)-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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