{"id":4202,"date":"2021-05-21T03:40:09","date_gmt":"2021-05-20T19:40:09","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4202"},"modified":"2021-05-21T03:40:09","modified_gmt":"2021-05-20T19:40:09","slug":"extended-knowledge-of-709-04-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4202","title":{"rendered":"Extended knowledge of 709-04-6"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 709-04-6, name is 1-Phenyl-1H-pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 709-04-6, category: pyrazoles-derivatives<\/a><\/p>\n

To a solution of nitrile 1011(300 mg, 1.77 mmol) in TI-IF (3 mL) was added Ti(O4Pr)4 (0.6 mL, 194 mmoi) at room temperature. Grignard reagent (4.5 mL, 443 mmoi)was added to the reaction mixture dropwise under argon atmosphere at -78C and the reaction mixture was stirred at -78C for 0.5 h and then at ambient temperature for 1 h. To the above reaction mixture at room temperature BF3OEt2 (0.5 mL, 3.54 rnrnoi) was added and stirred for I it After completion of reaction, the reaction mixture was quenched with water (3.0 mL), 2M HCI (2.0 mL) up to pI-i:::3 and stirred for 15 miii and then basified with 6N NaOH up to pH:::iO.The reaction mixture was extracted with 10% CH2C12\/MeOH (15 mE >< 3). The combined organic layers were dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude residue was further purified by Combifiash column chromatography (CH?Cl2\/I4eOH. 0 to 10%) to afford 1012 (60 mg, 1 7%) as an oil. MS (MM) miz 19g. I [M-4-H] -F.\n\nIn the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Phenyl-1H-pyrazole-4-carbonitrile, other downstream synthetic routes, hurry up and to see.\n\nReference:
Patent; IOMET PHARMA LTD.; MERCK SHARP & DOHME CORP.; COWLEY, Phillip, M.; HAN, Yongxin; (67 pag.)WO2017\/48612; (2017); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Phenyl-1H-pyrazole-4-carbonitrile, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[686,131],"tags":[126],"class_list":["post-4202","post","type-post","status-publish","format-standard","hentry","category-709-04-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nExtended knowledge of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 709-04-6, name is 1-Phenyl-1H-pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 709-04-6, category: pyrazoles-derivatives\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4202\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Extended knowledge of\" \/>\n<meta property=\"og:description\" content=\"Adding a certain compound to certain chemical reactions, such as: 709-04-6, name is 1-Phenyl-1H-pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Extended knowledge of","description":"Adding a certain compound to certain chemical reactions, such as: 709-04-6, name is 1-Phenyl-1H-pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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