{"id":4192,"date":"2021-05-21T03:39:14","date_gmt":"2021-05-20T19:39:14","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4192"},"modified":"2021-05-21T03:39:14","modified_gmt":"2021-05-20T19:39:14","slug":"brief-introduction-of-19959-77-4-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4192","title":{"rendered":"Brief introduction of 19959-77-4"},"content":{"rendered":"<p>Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19959-77-4, name is 2-(5-Methyl-1H-pyrazol-3-yl)pyridine, This compound has unique chemical properties. The synthetic route is as follows., <a href=\"https:\/\/www.ambeed.com\/products\/19959-77-4.html\">category: pyrazoles-derivatives<\/a><\/p>\n<p>To a solution of 2-(5-methyl-1H-pyrazol-3-yl)pyridine (27.9 g, 175 mmol) in carbon tetrachloride (300 mL) and dicholoromethane (300 mL) in a round-bottom flask was added N-bromosuccunimide (31.2 g, 175 mmol). The resulting mixture was stirred at room temperature for 21 hours and the reaction mixture was added water. The resulting solution was extracted with dicholomethane. The organic extracts were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting solid was washed with hexane\/AcOEt (v\/v =10\/1) and dried under reduced pressure at 50 C. The title compound was obtained as a white solid. (37.5 g, 158 mmol, 90% yield): 1H NMR (400 MHz, CDCl3) d 8.61 (d, J = 3.1 Hz, 1H), 8.28 (d, J = 7.8 Hz, 1H), 7.80 (t, J = 7.8 Hz, 1H), 7.28 (t, J = 7.8 Hz, 1H), 2.34 (s, 3H).<\/p>\n<p>According to the analysis of related databases, 19959-77-4, the application of this compound in the production field has become more and more popular.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.bmcl.2017.07.004\">Article; Fukuda, Takeshi; Goto, Riki; Kiho, Toshihiro; Ueda, Kenjiro; Muramatsu, Sumie; Hashimoto, Masami; Aki, Anri; Watanabe, Kengo; Tanaka, Naoki; Bioorganic and Medicinal Chemistry Letters; vol. 27; 16; (2017); p. 3716 &#8211; 3722;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>According to the analysis of related databases, 19959-77-4, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[234,131],"tags":[126],"class_list":["post-4192","post","type-post","status-publish","format-standard","hentry","category-19959-77-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Brief introduction of<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19959-77-4, name is 2-(5-Methyl-1H-pyrazol-3-yl)pyridine, This compound has unique chemical properties. 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