{"id":4189,"date":"2021-05-21T03:39:14","date_gmt":"2021-05-20T19:39:14","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4189"},"modified":"2021-05-21T03:39:14","modified_gmt":"2021-05-20T19:39:14","slug":"simple-exploration-of-methyl-4-iodo-1-methyl-1h-pyrazole-3-carboxylate","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4189","title":{"rendered":"Simple exploration of Methyl 4-iodo-1-methyl-1H-pyrazole-3-carboxylate"},"content":{"rendered":"<p>Adding a certain compound to certain chemical reactions, such as: 75092-25-0, name is Methyl 4-iodo-1-methyl-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound  75092-25-0, <a href=\"https:\/\/www.ambeed.com\/products\/75092-25-0.html\">Product Details of 75092-25-0<\/a><\/p>\n<p>5.1.51 Methyl 1-methyl-4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazole-3-carboxylate (36) To a mixture of 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one (34, 2.3 g, 9.78 mmol) and methyl 4-iodo-1-methyl-1H-pyrazole-3-carboxylate (35, 1.25 g, 4.70 mmol) in DMF (40 mL) and water (10 mL) were added Pd(PPh3)4 (814 mg, 0.71 mmol) and Cs2CO3 (3.06 g, 9.40 mmol), and the mixture was stirred at 80 C for 12 h. The mixture was concentrated in vacuo, and the residue was purified by silica gel column chromatography (0-5% MeOH in CHCl3) to give 36 (812 mg, 70%) as colorless solid. 1H NMR (DMSO-d6) delta 3.44 (s, 3H), 3.74 (s, 3H), 3.91 (s, 3H), 6.39 (d, 1H, J = 9.3 Hz), 7.51 (dd, 1H, J = 9.4, 2.6 Hz), 7.86 (d, 1H, J = 2.6 Hz), 7.94 (s, 1H); MS (ESI) m\/z 248 [M+H]+.<\/p>\n<p>At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 4-iodo-1-methyl-1H-pyrazole-3-carboxylate, and friends who are interested can also refer to it.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.bmc.2014.11.039\">Article; Hamaguchi, Wataru; Masuda, Naoyuki; Miyamoto, Satoshi; Shiina, Yasuhiro; Kikuchi, Shigetoshi; Mihara, Takuma; Moriguchi, Hiroyuki; Fushiki, Hiroshi; Murakami, Yoshihiro; Amano, Yasushi; Honbou, Kazuya; Hattori, Kouji; Bioorganic and Medicinal Chemistry; vol. 23; 2; (2015); p. 297 &#8211; 313;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 4-iodo-1-methyl-1H-pyrazole-3-carboxylate, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[649,131],"tags":[127],"class_list":["post-4189","post","type-post","status-publish","format-standard","hentry","category-75092-25-0","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Simple exploration of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 75092-25-0, name is Methyl 4-iodo-1-methyl-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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