{"id":4180,"date":"2021-05-21T03:39:14","date_gmt":"2021-05-20T19:39:14","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4180"},"modified":"2021-05-21T03:39:14","modified_gmt":"2021-05-20T19:39:14","slug":"introduction-of-a-new-synthetic-route-about-1-1-ethoxyethyl-4-iodo-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4180","title":{"rendered":"Introduction of a new synthetic route about 1-(1-Ethoxyethyl)-4-iodo-1H-pyrazole"},"content":{"rendered":"

Reference of 575452-22-1<\/a>, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 575452-22-1, name is 1-(1-Ethoxyethyl)-4-iodo-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.<\/p>\n

To a solution of 1-(1-etboxyethyl)-4-iodo-IH-pyrazole (84a)(5 g, 18.79 mmol)(Prepared as reported by Lin, Qiyan et al; Organic Leilers I 1(9): 1999-2002 (2009)) in ether (16 mL) cooled to -78C was added dropwise a solution of n-butyllithium (12.0 mL, 19.2rnmol) in hexane followed by stirring for 30 mins at -78 C. To the anion formed was addeda solution of 3-nitrobenzaldehyde (31a) (2.87 g, 18.79 mmol) in THF (24 mL) slowly at -78 C, stirred at -78 C for 2 h and then at room temperature for 2 h. The reaction mixturewas quenched with saturated amnionium chloride (50 m.L). The organic layer was separatedand the aqueous phase was extracted with ethyl acetate (75 mL). The organic layers werecombined washed with brine (60 rnL), dried over MgSO4, filtered and concentrated invacuum. The residue obtained was purified by flash column chromatography [(silica gel 80 g, eluting with hexanes\/ethyl acetate (1:0 to 1: 1)] to furnish (I -(I -ethoxyethyl)- I H-pyrazol4-yl)(3-nitrophenyl)methanol (84b) (3.537 g, 64.6%) as a yellow gum; ?H NMR (300 MHz, DMSO-d4) 8.24 (s, I H), 8.11 (ddd, .1 = 8.1, 2.4, 1.1 Hz, I H), 7.82 (ddq, .1 = 7.8, 1.8, 1.0Hz, 1.H), 7.74 (d, .1 0.8 Hz, I H), 7.63 (t, J 7.9 Hz, 1H), 7.37 (s, 1 H), 6.04 (dd, .1 4.8,1.6 Hz, IH), 5.85 (d,.J=4.7 Hz, lH), 5.47 (q,J= 6.0 Hz, IH), 3.43 -3.35 (m, lH). 3.23-3.05 (rn, IH), 1.54 (d, J 6.0 Hz, 3H), 1.00 (td, J = 7.0, 0.6 Hz, 3H); MS (ES+) 314.184M+Na).<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(1-Ethoxyethyl)-4-iodo-1H-pyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n

Reference:
Patent; BIOCRYST PHARMACEUTICALS, INC.; KOTIAN, Pravin, L.; BABU, Yarlagadda, S.; WU, Minwan; CHINTAREDDY, Venkat, R.; KUMAR, V., Satish; ZHANG, Weihe; WO2015\/134998; (2015); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(1-Ethoxyethyl)-4-iodo-1H-pyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[600,131],"tags":[127],"class_list":["post-4180","post","type-post","status-publish","format-standard","hentry","category-575452-22-1","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nIntroduction of a new synthetic route about<\/title>\n<meta name=\"description\" content=\"Reference of 575452-22-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 575452-22-1, name is 1-(1-Ethoxyethyl)-4-iodo-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4180\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Introduction of a new synthetic route about\" \/>\n<meta property=\"og:description\" content=\"Reference of 575452-22-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 575452-22-1, name is 1-(1-Ethoxyethyl)-4-iodo-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4180\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-20T19:39:14+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4180\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4180\",\"name\":\"Introduction of a new synthetic route about\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-05-20T19:39:14+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Reference of 575452-22-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 575452-22-1, name is 1-(1-Ethoxyethyl)-4-iodo-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4180#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=4180\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4180#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Introduction of a new synthetic route about 1-(1-Ethoxyethyl)-4-iodo-1H-pyrazole\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Introduction of a new synthetic route about","description":"Reference of 575452-22-1, In the next few decades, the world population will flourish. 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