{"id":4177,"date":"2021-05-21T03:39:14","date_gmt":"2021-05-20T19:39:14","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4177"},"modified":"2021-05-21T03:39:14","modified_gmt":"2021-05-20T19:39:14","slug":"brief-introduction-of-709-04-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4177","title":{"rendered":"Brief introduction of 709-04-6"},"content":{"rendered":"

Synthetic Route of 709-04-6<\/a>, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 709-04-6, name is 1-Phenyl-1H-pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.<\/p>\n

To a solution of nitrile 1011 (6.0 g, 35.5 mrnol) in THF (70 mL) at 0C was addedTi(O-i-Pr)4 (11.09 rnL, 39.05 rnmoi). To the above reaction mixture under argon atmosphere the1M solution of Grignard reag.ent in THF (78.1 mL, 78.1 mmoi) was added dropwise and thereaction mixture was stirred at —78C for 0.5 h. Then the reaction mixture was stirred at 0C for1.5 h. BF3OEt2 (10.0 rnL, 71.1 mrnol) was added to the above reaction mixture which wasstirred for 0.5 h. After completion of the reaction, the reaction mixture was treated with HCI (2N, 30 mL) and stirred for 15 mm and then basified with 6N NaOH. The mixture was extracted with ethyl acetate (3 x 100 mL) and the organic layers dried over anliydrous Na2SO,, and concentrated under reduced pressure. The crude residue was further purified by Combifiash column chromatography (ethyl acetate\/hexane, 0 to 100%) to separate racemic 1021 A (1.0 g)(trans) and racernic 102 lB (0.8 g) (cis) oils.MS (MM) m\/: 214.1[M\u00b1F1]\/<\/p>\n

The synthetic route of 1-Phenyl-1H-pyrazole-4-carbonitrile has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; IOMET PHARMA LTD.; MERCK SHARP & DOHME CORP.; COWLEY, Phillip, M.; HAN, Yongxin; (67 pag.)WO2017\/48612; (2017); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 1-Phenyl-1H-pyrazole-4-carbonitrile has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[686,131],"tags":[126],"class_list":["post-4177","post","type-post","status-publish","format-standard","hentry","category-709-04-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nBrief introduction of<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 709-04-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 709-04-6, name is 1-Phenyl-1H-pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4177\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Brief introduction of\" \/>\n<meta property=\"og:description\" content=\"Synthetic Route of 709-04-6, In the next few decades, the world population will flourish. 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