{"id":4173,"date":"2021-05-19T03:55:08","date_gmt":"2021-05-18T19:55:08","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4173"},"modified":"2021-05-19T03:55:08","modified_gmt":"2021-05-18T19:55:08","slug":"research-on-new-synthetic-routes-about-1-benzyl-4-bromo-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4173","title":{"rendered":"Research on new synthetic routes about 1-Benzyl-4-bromo-1H-pyrazole"},"content":{"rendered":"

Reference of 50877-41-3<\/a>,Some common heterocyclic compound, 50877-41-3, name is 1-Benzyl-4-bromo-1H-pyrazole, molecular formula is C10H9BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

Step 2: Preparation of l-benzyl-4-(l-ethoxyvinyl)-lH-pyrazole [00168] Nitrogen was purged into a solution of l-benzyl-4-bromo-lH-pyrazole (0.55 g, 2.32 mmol) and tributyl(l-ethoxyvinyl)stannane (0.862 niL, 2.55 mmol) in toluene (15 niL) for 15 minutes. Then tetrakis(triphenylphosphine)palladium(0) (0.134 g, 0.116 mmol) was added and the reaction mixture was heated at 110 C for 12 h. The reaction mixture was filtered through celite and the filtrate was evaporated to afford the title compound l-benzyl-4-(l-ethoxyvinyl)- lH-pyrazole (0.52 g, crude) as a black liquid. The crude material was as such taken for next step without further purification.<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Benzyl-4-bromo-1H-pyrazole, its application will become more common.<\/p>\n

Reference:
Patent; MNEMOSYNE PHARMACEUTICALS, INC.; ANDERSON, David, R.; VOLKMANN, Robert, A.; MENNITI, Frank, S.; (181 pag.)WO2016\/49165; (2016); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Benzyl-4-bromo-1H-pyrazole, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[685,131],"tags":[127],"class_list":["post-4173","post","type-post","status-publish","format-standard","hentry","category-50877-41-3","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nResearch on new synthetic routes about<\/title>\n<meta name=\"description\" content=\"Reference of 50877-41-3,Some common heterocyclic compound, 50877-41-3, name is 1-Benzyl-4-bromo-1H-pyrazole, molecular formula is C10H9BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4173\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research on new synthetic routes about\" \/>\n<meta property=\"og:description\" content=\"Reference of 50877-41-3,Some common heterocyclic compound, 50877-41-3, name is 1-Benzyl-4-bromo-1H-pyrazole, molecular formula is C10H9BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4173\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-18T19:55:08+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4173\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4173\",\"name\":\"Research on new synthetic routes about\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-05-18T19:55:08+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Reference of 50877-41-3,Some common heterocyclic compound, 50877-41-3, name is 1-Benzyl-4-bromo-1H-pyrazole, molecular formula is C10H9BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4173#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=4173\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4173#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research on new synthetic routes about 1-Benzyl-4-bromo-1H-pyrazole\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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