{"id":4167,"date":"2021-05-19T03:55:08","date_gmt":"2021-05-18T19:55:08","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4167"},"modified":"2021-05-19T03:55:08","modified_gmt":"2021-05-18T19:55:08","slug":"simple-exploration-of-920006-32-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4167","title":{"rendered":"Simple exploration of 920006-32-2"},"content":{"rendered":"

Synthetic Route of 920006-32-2<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 920006-32-2 name is 1-Isopropylpyrazole-5-carboxylic Acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n

To a solution of HATU (0.253 g) in DMF (3 ml) was added 1 -(1 -methylethyl)-1 H-pyrazole- 5-carboxylic acid (0.102 g) and DIPEA (0.21 1 ml) and the mixure was left to stand for 10 min. 6-(1 H-lndol-4-yl)-1 H-indazol-4-amine (0.075 g) dissolved in DMF (3 ml) was added and the solution was left to stand at RT for 18 h. DMF was removed by blow down (not to dryness) and the residue was dissolved in chloroform (1 ml) and loaded onto an aminopropyl SPE (2 g) (pre-conditioned with methanol (6 ml) and chloroform (6 ml)). The mixure was left on the column for 2 h then eluted with ethyl acetate:methanol (1 :1 , 10 ml). The solvent was blown down to dryness and the residue was dissolved in DMSO:methanol (1 ml, 1 :1 ) and purified by MDAP (method A). The solvent was removed in vacuo and dried in an vacuum oven (50 C) overnight to give title compound, 18 mg. LCMS (method A) Rt = 3.23 min, MH+ = 385.<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Isopropylpyrazole-5-carboxylic Acid, and friends who are interested can also refer to it.<\/p>\n

Reference:
Patent; GLAXO GROUP LIMITED; BALDWIN, Ian, Robert; DOWN, Kenneth, David; FAULDER, Paul; GAINES, Simon; HAMBLIN, Julie, Nicole; LE, Joelle; LUNNISS, Christopher, James; PARR, Nigel, James; RITCHIE, Timothy, John; ROBINSON, John, Edward; SIMPSON, Juliet, Kay; SMETHURST, Christian, Alan, Paul; WO2011\/67364; (2011); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Isopropylpyrazole-5-carboxylic Acid, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[615,131],"tags":[126],"class_list":["post-4167","post","type-post","status-publish","format-standard","hentry","category-920006-32-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSimple exploration of<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 920006-32-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 920006-32-2 name is 1-Isopropylpyrazole-5-carboxylic Acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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