{"id":4165,"date":"2021-05-19T03:54:18","date_gmt":"2021-05-18T19:54:18","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4165"},"modified":"2021-05-19T03:54:18","modified_gmt":"2021-05-18T19:54:18","slug":"extended-knowledge-of-c7h10n2o2-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4165","title":{"rendered":"Extended knowledge of C7H10N2O2"},"content":{"rendered":"

Reference of 436096-96-7<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 436096-96-7 as follows.<\/p>\n

Preparation 68: [3′-(4-Fluorophenyl)-2,3,5,6-tetrahydro-[l,2′]bipyrazinyl-4-yl]-(l- isopropyl-lH-pyrazol-4-yl)-methanone Dissolve l-isopropyl-lH-pyrazole-4-carboxylic acid (0.120 g, 0.780 mmol) inDCM (5 mL). Add etaOBt (0.088 g, 0.650 mmol) followed by l-(3-dimethyl- aminopropyl)-3-ethylcarbodiimide hydrochloride (0.125 g, 0.650 mmol). Add 3′-(4- fluorophenyl)-3,4,5,6-tetrahydro-2eta-[l,2′]bipyrazinyl (0.168 g, 0.650 mmol) and stir at room temperature for 18 hr. Add DCM and water and separate layers. Extract aqueous layer 3 times with DCM, dry (magnesium sulfate), filter, concentrate and purify (silica gel chromatography, eluting with 25:75 to 100:0 ethylacetate\/hexanes), to give the title preparation (211 mg, 82%). MS (ES): m\/z = 395 [M+H]+.<\/p>\n

According to the analysis of related databases, 436096-96-7, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; ELI LILLY AND COMPANY; WO2008\/141020; (2008); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 436096-96-7, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[681,131],"tags":[126],"class_list":["post-4165","post","type-post","status-publish","format-standard","hentry","category-436096-96-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nExtended knowledge of<\/title>\n<meta name=\"description\" content=\"Reference of 436096-96-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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