{"id":4164,"date":"2021-05-19T03:54:18","date_gmt":"2021-05-18T19:54:18","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4164"},"modified":"2021-05-19T03:54:18","modified_gmt":"2021-05-18T19:54:18","slug":"extended-knowledge-of-c18h24n4o3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4164","title":{"rendered":"Extended knowledge of C18H24N4O3"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 139756-04-0, name is 1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide, A new synthetic method of this compound is introduced below., Product Details of 139756-04-0<\/a><\/p>\n

EXAMPLE 113 1-Methyl-5-(2-n-propoxyphenyl)-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 1-Methyl-4-(2-n-propoxybenzamido)-3-n-propylpyrazole-5-carboxamide (0.34 g, 0.99 mmol) was added to a stirred mixture of 30% hydrogen peroxide solution (1.0 ml), potassium carbonate (0.54 g, 3.92 mmol), water (10 ml) and ethanol (5 ml). The mixture was heated under reflux for 38 hours and then evaporated under vacuum. The residue was suspended in water (20 ml), then the mixture acidified with 2N hydrochloric acid and extracted with dichloromethane (3*20 ml). The extracts are combined, dried (Na2SO4) and evaporated under vacuum. The resulting residue was chromatographed on silica gel (6 g), using a methanol in dichloromethane elution gradient (0.0-1.0%), to give an oil, successive trituration of which with ether gave the required product as a white solid (0.19 g, 59%), m.p. 111-114 C. Found: C, 66.26; H, 6.92; N, 17.15. C18H22N4O2 requires C, 66.23; H, 6.80; N, 17.17%.<\/p>\n

The synthetic route of 139756-04-0 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; Cell Pathways, Inc.; US6200980; (2001); B1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 139756-04-0 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[616,131],"tags":[167],"class_list":["post-4164","post","type-post","status-publish","format-standard","hentry","category-139756-04-0","category-pyrazoles-derivatives","tag-m-w300-400"],"yoast_head":"\nExtended knowledge of<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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