{"id":4142,"date":"2021-05-18T03:49:32","date_gmt":"2021-05-17T19:49:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4142"},"modified":"2021-05-18T03:49:32","modified_gmt":"2021-05-17T19:49:32","slug":"research-on-new-synthetic-routes-about-c5h6n2o","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4142","title":{"rendered":"Research on new synthetic routes about C5H6N2O"},"content":{"rendered":"

Application of 3273-44-7<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3273-44-7 as follows.<\/p>\n

General procedure: To a suspension of 5-methyl-1H-pyrazole-3-carbaldehyde (18; 2-6 equiv) in anhydrous THF (10 mL) (in the case of the synthesis of 1) or MeOH (in the case of the synthesis of 2-5 and 11), the corresponding derivative bearing one to three amino groups (17,21 25-289d,11 or 36,4c see Scheme 1 and Scheme 2) (1 equiv), dissolved in anhydrous MeOH (5 mL), was added. The resulting mixture was heated at reflux until a clear solution resulted and then stirred at r.t. (up to 4 days, TLC analysis). The resulting imines were reduced without further purification by addition of NaBH4 (3-9 equiv) in portions. After complete addition of the reducing agent, the reaction mixture was stirred for 24 h at r.t. and then the solvent was removed under reduced pressure. The residue was suspended in CHCl3-H2O (1:1, 10 mL) and stirred for 12 h at r.t. The resulting suspension was extracted with CHCl3 (3 \u00d7 20 mL), dried over MgSO4, and the solvent was removed. The crude product was purified by column chromatography.<\/p>\n

According to the analysis of related databases, 3273-44-7, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Article; Koch, Niklas; Seichter, Wilhelm; Mazik, Monika; Synthesis; vol. 48; 17; (2016); p. 2757 – 2767;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 3273-44-7, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[640,131],"tags":[126],"class_list":["post-4142","post","type-post","status-publish","format-standard","hentry","category-3273-44-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nResearch on new synthetic routes about<\/title>\n<meta name=\"description\" content=\"Application of 3273-44-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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