{"id":4141,"date":"2021-05-18T03:49:32","date_gmt":"2021-05-17T19:49:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4141"},"modified":"2021-05-18T03:49:32","modified_gmt":"2021-05-17T19:49:32","slug":"discovery-of-75092-30-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4141","title":{"rendered":"Discovery of 75092-30-7"},"content":{"rendered":"

75092-30-7, name is 4-Iodo-1-methyl-1H-pyrazole-5-carboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 4-Iodo-1-methyl-1H-pyrazole-5-carboxylic acid<\/a><\/p>\n

Step 1. 4-[(4-Benzylphenyl)amino]-1-methyl-1H-pyrazole-5-carboxylic acid A mixture of 4-iodo-1-methyl-1H-pyrazole-5-carboxylic acid ((Manaev, Yu. A. et al., J. Gen. Chem. USSR (Engl. Transl.), 1982, 52 (11), 2291), 8.0 g, 31.74 mmol), 4-benzylaniline (21.03 g, 114.76 mmol) and copper powder (3.2 g) in a mixture of 5% aqueous sodium carbonate (160 ml) and dimethylsulfoxide (80 ml) was stirred for 17 h at 100 C. After cooling to room temperature, the mixture was filtered through a pad of Celite, which was washed with water, 2N aqueous sodium hydroxide and diethyl ether. The separated water layer was washed with diethyl ether (100 ml*2). The water layer was acidified with concentrated hydrochloric acid and the formed solid was collected by filtration, dried, to give 4.86 g (50%) of the pure title compound as a pale brown solid. Rf value: 0.50 (methanol\/dichloromethane\/acetic acid=1\/10\/2 drops). 1H-NMR (DMSO-d6) delta: 7.63 (1 H, s), 7.50 (1 H, br s), 7.31-6.96 (9 H, m), 4.00 (3 H, s), 3.85 (2 H, s). One signal was not observed.<\/p>\n

The synthetic route of 75092-30-7 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; Kawamura, Kiyoshi; Mihara, Sachiko; Nukui, Seiji; Uchida, Chikara; US2003\/130277; (2003); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 75092-30-7 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[639,131],"tags":[127],"class_list":["post-4141","post","type-post","status-publish","format-standard","hentry","category-75092-30-7","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nDiscovery of<\/title>\n<meta name=\"description\" content=\"75092-30-7, name is 4-Iodo-1-methyl-1H-pyrazole-5-carboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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