{"id":4136,"date":"2021-05-18T03:49:32","date_gmt":"2021-05-17T19:49:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4136"},"modified":"2021-05-18T03:49:32","modified_gmt":"2021-05-17T19:49:32","slug":"introduction-of-a-new-synthetic-route-about-6647-93-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4136","title":{"rendered":"Introduction of a new synthetic route about 6647-93-4"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6647-93-4 as follows. category: pyrazoles-derivatives<\/a><\/p>\n

A suspension of 4-iodo- 1 H-pyrazole-3-carboxylic acid Compound la(500 mg, 2.101 mmol), 4-methoxy-benzene-l ,2-diamine dihydrochloride (443 mg, 2.101 mmol), HATU (799 mg, 2.101 mmol), and diisopropyl ethylamine (815 mg, 6.303 mmol) in 15 ml DMF was stirred at 50 C for 16 hrs. After cooled to rt, the mixture was diluted with 150 ml EtOAc, washed with water (7 times) and brine, then dried with Na2SO4. Evaporation give 4-iodo- 1 H-pyrazole-3-carboxylic acid (2-amino-5-methoxy-phenyl)-amide Compound Ib (615 mg, 81.7 %) as a yellowish powder. NMR (DMSO): delta 3.70 (s, 3H), 6.20 (m, IH), 6.46 (s, H), 7.12 (d, J=8.0 Hz, IH), 8.10 (s, IH). MS m\/z 358 (MH+).<\/p>\n

According to the analysis of related databases, 6647-93-4, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008\/48502; (2008); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 6647-93-4, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[672,131],"tags":[127],"class_list":["post-4136","post","type-post","status-publish","format-standard","hentry","category-6647-93-4","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nIntroduction of a new synthetic route about<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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