{"id":4107,"date":"2021-05-17T04:34:52","date_gmt":"2021-05-16T20:34:52","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4107"},"modified":"2021-05-17T04:34:52","modified_gmt":"2021-05-16T20:34:52","slug":"simple-exploration-of-149978-43-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4107","title":{"rendered":"Simple exploration of 149978-43-8"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 149978-43-8, name is 2-Methyl-5-trifluoromethyl-2H-pyrazol-3-ylamine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 149978-43-8<\/a><\/p>\n

Hydrochloric acid in 1,4-dioxane (10.5 mL, 42.0 mmol, 4 mol\/L) followed by 1,1′- thiocarbonyldiimidazole (4.38 g, 23.3 mmol) were added to a stirred solution of l-methyl-3- (trifluoromethyl)-lH-pyrazol-5-amine [149978-43-8] (3.49 g, 21.1 mmol) in DCM (63 mL) under nitrogen. The reaction mixture was stirred at rt for 4.5 h before being left without stirring for a further 15.5 h. The reaction mixture was filtered and the pale yellow solid was washed with DCM (2 x 40 mL). The filtrate and washings were concentrated in vacuo to give an orange liquid which was purified by flash column chromatography on silica (gradient elution with 0% to 15% EtOAc in isohexane) to afford the title compound (3.0430 g, 14.688 mmol, 70%) as a colourless liquid. To confirm the presence of the title compound, a few drops of isobutylamine were added to the LCMS sample of the product before analysis to give the thiourea, LCMS [M+H]+ 281.0, RT 1.336 minutes, purity 100% (Method 15).<\/p>\n

According to the analysis of related databases, 149978-43-8, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; UCB BIOPHARMA SRL; CHOVATIA, Prafulkumar Tulshibhai; CONNELLY, Rickki Lee; FRANKLIN, Richard Jeremy; HASLETT, Gregory William; HENRY, Alistair James; MADDEN, James; NEUSS, Judi Charlotte; NORMAN, Timothy John; PHILPS, Oliver; PITT, William Ross; RAMPALAKOS, Konstantinos; SELBY, Matthew Duncan; SELVARATNAM, Suganthan; TRANI, Giancarlo; ZHU, Zhaoning; (768 pag.)WO2019\/243550; (2019); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 149978-43-8, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[653,131],"tags":[126],"class_list":["post-4107","post","type-post","status-publish","format-standard","hentry","category-149978-43-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSimple exploration of<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 149978-43-8, name is 2-Methyl-5-trifluoromethyl-2H-pyrazol-3-ylamine, This compound has unique chemical properties. 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