{"id":4089,"date":"2021-05-17T04:33:53","date_gmt":"2021-05-16T20:33:53","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4089"},"modified":"2021-05-17T04:33:53","modified_gmt":"2021-05-16T20:33:53","slug":"sources-of-common-compounds-c7h10n2o2-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4089","title":{"rendered":"Sources of common compounds: C7H10N2O2"},"content":{"rendered":"

Some common heterocyclic compound, 10250-59-6, name is Methyl 1,3-dimethyl-1H-pyrazole-5-carboxylate, molecular formula is C7H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C7H10N2O2<\/a><\/p>\n

Example 1 : Preparation of N-(2,5-dimethyl-2H-pyrazol-3-ylmethyl)-4-(5-trifluormethyl- pyridin-2-yloxy)-benzenesulfonamide (Table I: example 1-21 )Example 1.1 : Preparation of (2,5-dimethyl-2H-pyrazol-3-yl)-methanol At 25 to 300C 25 ml of a 1 molar solution of lithium aluminium hydride in diethylether was added dropwise to 4.5 g 2,5-dimethyl-2H-pyrazole-3-caboxylic acid methyl ester in 50 ml diethylether. A solid precipitated and the reaction mixture was stirred for about 2 to 3 days at about 20 to 25C. After dilution of the reaction mixture with 50 ml of MTBE a little volume of water was added. After filtration the precipitated wet solid was thoroughly washed with ethyl acetate. The solvent was removed in vacuo from the combined filtrate and washing fluids to yield 3.7 g of the title compound. 1H-NMR (CDCI3, delta in ppm): 5.9 (s, 1 H); 4.6 (s, 2H); 4.0 (s, broad, 1 H); 3.75 (s, 3H); 2.2 (s, 3H).<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 10250-59-6, its application will become more common.<\/p>\n

Reference:
Patent; BASF SE; WO2009\/101082; (2009); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 10250-59-6, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[656,131],"tags":[126],"class_list":["post-4089","post","type-post","status-publish","format-standard","hentry","category-10250-59-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSources of common compounds:<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 10250-59-6, name is Methyl 1,3-dimethyl-1H-pyrazole-5-carboxylate, molecular formula is C7H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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