{"id":4086,"date":"2021-05-17T04:33:53","date_gmt":"2021-05-16T20:33:53","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4086"},"modified":"2021-05-17T04:33:53","modified_gmt":"2021-05-16T20:33:53","slug":"simple-exploration-of-25700-12-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4086","title":{"rendered":"Simple exploration of 25700-12-3"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25700-12-3, name is 3-(1H-Pyrazol-1-yl)pyridine, A new synthetic method of this compound is introduced below., category: pyrazoles-derivatives<\/a><\/p>\n

Under argon, 3-(4-bromopyrazol-1-yl)pyridine (1.00 g, 4.46 mmol), 1,1′-bis(diphenylphosphino)-ferrocene (dppf) (74 mg, 0.13 mmol), palladium dichloride-dppf (109 mg, 0.13 mmol), potassium acetate (1.31 g, 13.3 mmol) and pinacolatodiborane (1.19 g, 4.68 mmol) were added to dioxane (11 ml). The mixture was heated under reflux for 24 h and then cooled. The solvent was removed on a rotary evaporator under reduced pressure, dichloromethane (100 ml) and water (100 ml) were added to the residue, and the solids formed were filtered off with suction and discarded. The filtrate was extracted with dichloromethane and the organic phase was dried over magnesium sulphate. The solvent was removed on a rotary evaporator under reduced pressure and the residue was chromatographed (ethyl acetate, cyclohexane).Yield: 680 mg (55% of theory), logP(HCOOH) 2.19, [M++1] 272.21H NMR (d6-DMSO): 1.30 (s, 12H), 7.51 (m, 1H), 7.90 (s, 1H), 8.25 (m, 1H), 8.51 (m, 1H), 8.73 (s, 1H), 9.12 (m, 1H).<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n

Reference:
Patent; BAYER CROPSCIENCE AG; US2012\/165345; (2012); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[606,131],"tags":[126],"class_list":["post-4086","post","type-post","status-publish","format-standard","hentry","category-25700-12-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSimple exploration of<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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