{"id":4079,"date":"2021-05-14T08:50:27","date_gmt":"2021-05-14T00:50:27","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4079"},"modified":"2021-05-14T08:50:27","modified_gmt":"2021-05-14T00:50:27","slug":"simple-exploration-of-873191-23-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4079","title":{"rendered":"Simple exploration of 873191-23-2"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/873191-23-2.html\">Related Products of 873191-23-2<\/a>, The chemical industry reduces the impact on the environment during synthesis 873191-23-2, name is 5-(Bromomethyl)-1,3-dimethyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.<\/p>\n<p>General procedure: The lycorine derivatives 10, 11 and 12 (0.1mmol) were dissolved in dry THF (10mL), and NaH (50mg, 2mmol) and 3-(bromomethyl)pyridine, 3-(Chloromethyl)-1,5-dimethyl-1H-pyrazole or 5-Bromomethyl-1,3-dimethyl-1H-pyrazole (1mmol) were added. The mixture was stirred at r. t. for 24h and quenched with H2O (50mL) in an ice bath. The solution was evaporated to remove the THF and extracted with CH2Cl2 (2\u00d730mL). The organic layer was washed with saturated NaHCO3 and brine, dried over MgSO4, filtered and concentrated. The residue was purified by column chromatography using petroleum ether-EtOAc as the eluent to afford compounds 5, 6, 7, 8 and 9. 8-((1,3-dimethyl-1H-pyrazol-5-yl)methoxy)-5-ethyl-4-methyl-5,6-dihydro- phenanthridine (5). 78% yield. Colorless amorphous powder (from CH2Cl2); 1H NMR (500MHz, CDCl3) delta 7.59 (d, J=8.5Hz, 1H), 7.50 (d, J=7.6Hz, 1H), 7.06 (d, J=8.0Hz, 1H), 7.00 (t, J=7.5Hz, 1H), 6.86 (dd, J=8.5, 2.6Hz, 1H), 6.74 (d, J=2.5Hz, 1H), 6.04 (s, 1H), 4.94 (s, 2H), 4.01 (s, 2H), 3.79 (s, 3H), 2.62 (q, J=7.1Hz, 2H), 2.29 (s, 3H), 2.19 (s, 3H), 1.01 (t, J=7.1Hz, 3H); 13C NMR (125MHz, CDCl3) delta 157.77 (C), 147.36 (C), 146.31 (C), 137.89 (C), 135.20 (C), 133.43 (C), 129.94 (CH), 129.12 (C), 126.72 (C), 124.38 (CH), 123.89 (CH), 120.90 (CH), 113.66 (CH), 112.84 (CH), 106.77 (CH), 60.61 (CH2), 50.18 (CH2), 46.12 (CH2), 36.50 (CH3), 17.79 (CH3), 13.63 (CH3), 13.43 (CH3); HRESIMS m\/z 348.2055 [M+H]+ (calcd for C22H26N3O, 348.2070).<\/p>\n<p>In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-(Bromomethyl)-1,3-dimethyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.ejmech.2018.08.064\">Article; Chen, Duozhi; Zhang, Heng; Jing, Chenxu; He, Xiaoli; Yang, Bijuan; Cai, Jieyun; Zhou, Yunfu; Song, Xiaoming; Li, Lin; Hao, Xiaojiang; European Journal of Medicinal Chemistry; vol. 157; (2018); p. 1491 &#8211; 1499;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-(Bromomethyl)-1,3-dimethyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[621,131],"tags":[126],"class_list":["post-4079","post","type-post","status-publish","format-standard","hentry","category-873191-23-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Simple exploration of<\/title>\n<meta name=\"description\" content=\"Related Products of 873191-23-2, The chemical industry reduces the impact on the environment during synthesis 873191-23-2, name is 5-(Bromomethyl)-1,3-dimethyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4079\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Simple exploration of\" \/>\n<meta property=\"og:description\" content=\"Related Products of 873191-23-2, The chemical industry reduces the impact on the environment during synthesis 873191-23-2, name is 5-(Bromomethyl)-1,3-dimethyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4079\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-14T00:50:27+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4079\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4079\",\"name\":\"Simple exploration of\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-05-14T00:50:27+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Related Products of 873191-23-2, The chemical industry reduces the impact on the environment during synthesis 873191-23-2, name is 5-(Bromomethyl)-1,3-dimethyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4079#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=4079\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4079#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Simple exploration of 873191-23-2\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Simple exploration of","description":"Related Products of 873191-23-2, The chemical industry reduces the impact on the environment during synthesis 873191-23-2, name is 5-(Bromomethyl)-1,3-dimethyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=4079","og_locale":"en_US","og_type":"article","og_title":"Simple exploration of","og_description":"Related Products of 873191-23-2, The chemical industry reduces the impact on the environment during synthesis 873191-23-2, name is 5-(Bromomethyl)-1,3-dimethyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=4079","og_site_name":"pyrazoles-derivatives","article_published_time":"2021-05-14T00:50:27+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=4079","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=4079","name":"Simple exploration of","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2021-05-14T00:50:27+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Related Products of 873191-23-2, The chemical industry reduces the impact on the environment during synthesis 873191-23-2, name is 5-(Bromomethyl)-1,3-dimethyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=4079#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=4079"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=4079#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"https:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Simple exploration of 873191-23-2"}]},{"@type":"WebSite","@id":"https:\/\/www.pyrazoles-derivatives.com\/#website","url":"https:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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