{"id":4070,"date":"2021-05-14T08:49:37","date_gmt":"2021-05-14T00:49:37","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4070"},"modified":"2021-05-14T08:49:37","modified_gmt":"2021-05-14T00:49:37","slug":"brief-introduction-of-75092-25-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4070","title":{"rendered":"Brief introduction of 75092-25-0"},"content":{"rendered":"<p>Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75092-25-0, name is Methyl 4-iodo-1-methyl-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., <a href=\"https:\/\/www.ambeed.com\/products\/75092-25-0.html\">category: pyrazoles-derivatives<\/a><\/p>\n<p>To a mixture of methyl 4-iodo-1-methyl-1H-pyrazole-3-carboxylate(29; 263 mg, 0.99 mmol) and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (30; 1.01 g, 4.94 mmol) in DMF(3.4 mL) and H2O (1.0 mL) were added Cs2CO3 (644 mg, 1.98 mmol) and Pd(PPh3)4 (571 mg, 0.49 mmol), and the mixture was stirred at 80 C for 3 h. After the mixture was cooled at room temperature, the mixture was partitioned between water and EtOAc. The organic layer was washed with brine, dried over MgSO4, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (0-100% EtOAc inCHCl3) to give 31 (87 mg, 41%) a pale yellow oil. 1H NMR (DMSOd6) d 3.77 (s, 3H), 3.95 (s, 3H), 7.49 (d, 2H, J = 5.3 Hz), 8.22 (s,1H), 8.55 (d, 2H, J = 5.3 Hz); MS (ESI) m\/z 218 [M+H]+.<\/p>\n<p>According to the analysis of related databases, 75092-25-0, the application of this compound in the production field has become more and more popular.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.bmc.2015.04.052\">Article; Hamaguchi, Wataru; Masuda, Naoyuki; Miyamoto, Satoshi; Kikuchi, Shigetoshi; Narazaki, Fumie; Shiina, Yasuhiro; Seo, Ryushi; Amano, Yasushi; Mihara, Takuma; Moriguchi, Hiroyuki; Hattori, Kouji; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3351 &#8211; 3367;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>According to the analysis of related databases, 75092-25-0, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[649,131],"tags":[127],"class_list":["post-4070","post","type-post","status-publish","format-standard","hentry","category-75092-25-0","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Brief introduction of<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75092-25-0, name is Methyl 4-iodo-1-methyl-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. 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