{"id":4056,"date":"2021-05-14T08:49:37","date_gmt":"2021-05-14T00:49:37","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4056"},"modified":"2021-05-14T08:49:37","modified_gmt":"2021-05-14T00:49:37","slug":"a-new-synthetic-route-of-3-amino-5-ethylpyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4056","title":{"rendered":"A new synthetic route of 3-Amino-5-ethylpyrazole"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1904-24-1 as follows. Safety of 3-Amino-5-ethylpyrazole<\/a><\/p>\n

A. 4-(2,4-dichlorophenyl)-7-ethyl-2-methyl-pyrazolo[1,5-a]-1,3,5-triazine A mixture of 3-amino-5-ethylpyrazole (10.3 g, 39.3 mmol) and N-(1-(methylthio)ethylidene)-2,4-dichloro-benzamide (4.0 g, 35.7 mmol) in anhydrous dioxan (20 mL) was stirred at reflux temperatrue under a nitrogen atmosphere for 16 h. After being cooled to ambient temperature, the reaction mix was concentrated in vacuo and the residue was treated with dichloromethane. The resulting supsension was filtered and the filtrate was concentrated in vacuo to afford an oil (1.5 g, 14% yield): NMR (CDCl3, 300 MHz): delta 7.62 (d, 1H, J=8), 7.59 (d, 1H, J=2), 7.45 (dd, 1H, J=8,2), 6.42 (s, 1H), 2.82 (q, 2H, J=8), 2.73 (s, 3H), 1.30 (t, 3H, J=8).<\/p>\n

According to the analysis of related databases, 1904-24-1, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; Gilligan, Paul J.; Wilde, Richard G.; US2002\/147338; (2002); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 1904-24-1, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[644,131],"tags":[126],"class_list":["post-4056","post","type-post","status-publish","format-standard","hentry","category-1904-24-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nA new synthetic route of<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1904-24-1 as follows. 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