{"id":4050,"date":"2021-05-13T07:59:20","date_gmt":"2021-05-12T23:59:20","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4050"},"modified":"2021-05-13T07:59:20","modified_gmt":"2021-05-12T23:59:20","slug":"sources-of-common-compounds-1204298-65-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4050","title":{"rendered":"Sources of common compounds: 1204298-65-6"},"content":{"rendered":"

1204298-65-6, name is 5-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C6H6F2N2O2<\/a><\/p>\n

To a suspension of 6-(2-amino-5-chlorothiazol-4-yl)-3,4-dihydroquinolin-2(1H)-one (0.100 g, 0.41 mmol), 5-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (0.080 g, 0.45 mmol), pyridine (0.15 mL, 1.83 mmol) in acetonitrile (4 mL) in a sealed tube was added propylphosphonic anhydride solution (50 wt % in ethyl acetate, 0.61 mL, 1.02 mmol). The sealed tube was heated to 100 C. for 16 h. After cooling, the precipitate was collected by filtration and washed with cold 1:1 acetonitrile\/water to give 5-(difluoromethyl)-1-methyl-N-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)-1H-pyrazole-4-carboxamide (0.119 g, 72%). 1H NMR (400 MHz, DMSO-d): delta 12.74 (bs, 1H), 10.19 (s, 1H), 8.45 (s, 1H), 7.74 (m, 1H), 7.69 (dd, 1H, J=8.4, 2.0 Hz), 7.56 (t, JHF=54 Hz, 1H), 7.53 (s, 1H), 6.90 (d, 1H, J=8.0 Hz), delta, 4.04 (s, 3H), 2.93 (t, 2H, J=7.2 Hz), 2.48 (partial masked under d-DMSO, m, 2H); MS (ESI): Calcd. for C18H15F2N5O2S: 403, found 404 (M+1)+.<\/p>\n

The synthetic route of 1204298-65-6 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; Nantbio, Inc.; Tao, Chunlin; Nallan, Laxman; Ho, David G.; Wang, Qinwei; Weingarten, Paul; Juncker-Jensen, Anna B.; (121 pag.)US2018\/201610; (2018); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 1204298-65-6 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[643,131],"tags":[126],"class_list":["post-4050","post","type-post","status-publish","format-standard","hentry","category-1204298-65-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSources of common compounds:<\/title>\n<meta name=\"description\" content=\"1204298-65-6, name is 5-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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