{"id":4028,"date":"2021-05-13T07:58:32","date_gmt":"2021-05-12T23:58:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4028"},"modified":"2021-05-13T07:58:32","modified_gmt":"2021-05-12T23:58:32","slug":"the-important-role-of-c13h15n3o2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4028","title":{"rendered":"The important role of C13H15N3O2"},"content":{"rendered":"

15001-11-3, name is Ethyl 5-amino-1-(p-tolyl)-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 15001-11-3<\/a><\/p>\n

General procedure: Intermediate 4 (0.001mol) and 5 (0.001mol) were dissolved in pyridine, phosphorus oxychloride is slowly added dropwise under ice bath conditions, then at 40-60C reacted for 5-8h. Finally, the mixture was poured into 30mL saturated Na2CO3 solution and stirred well. After the mixture was acidified, the saturated CuSO4 solution was used to remove pyridine, which greatly improved the purity and yield of the product. The data for compounds 8I-8VI are provided in the supporting information.<\/p>\n

The synthetic route of 15001-11-3 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Article; Liu, Hao; Ren, Zi-Li; Wang, Wei; Gong, Jie-Xiu; Chu, Ming-Jie; Ma, Quan-Wei; Wang, Jie-Chun; Lv, Xian-Hai; European Journal of Medicinal Chemistry; vol. 157; (2018); p. 81 – 87;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 15001-11-3 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[630,131],"tags":[127],"class_list":["post-4028","post","type-post","status-publish","format-standard","hentry","category-15001-11-3","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nThe important role of<\/title>\n<meta name=\"description\" content=\"15001-11-3, name is Ethyl 5-amino-1-(p-tolyl)-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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