{"id":4013,"date":"2021-04-26T00:00:00","date_gmt":"2021-04-25T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4013"},"modified":"2021-04-26T00:00:00","modified_gmt":"2021-04-25T16:00:00","slug":"discovery-of-5-methyl-1h-pyrazole-3-carboxylic-acid","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4013","title":{"rendered":"Discovery of 5-Methyl-1H-pyrazole-3-carboxylic acid"},"content":{"rendered":"

Reference of 402-61-9<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 402-61-9 name is 5-Methyl-1H-pyrazole-3-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n

Example 1 lambda\/-[6-(1H-lndol-4-yl)-1H-indazol-4-yl]-5-methyl-1H-pyrazole-3-carboxamide 5-Methyl-1 H-pyrazole-3-carboxylic acid (10mg) in DMF (0.2ml) was treated with N- [(dimethylamino)(3H-[1 ,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylidene]-\/V- methylmethanaminium hexafluorophosphate (27mg) in DMF (0.2ml) and DIPEA (0.03ml). The reaction mixture was shaken for five min prior to treatment with 6-(1H-indol-4-yl)-2- (tetrahydro-2H-pyran-2-yl)-2H-indazol-4-amine (20mg) in DMF (0.2ml). The reaction mixture was shaken for five min and left to stand at 220C for 18h. The solvent was removed in vacuo and the product re-dissolved in methanol (1 ml) prior to application on to an SCX SPE cartridge (1g). The product was eluted after 1 h with 2M ammonia in methanol (2x3ml), the fractions were combined and concentrated under a stream of nitrogen using blow down apparatus. Purification by mass directed preparative HPLC (Method C) afforded the title compound. LC\/MS R1 2.91 min m\/z 357 [MH+]. Method A<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Methyl-1H-pyrazole-3-carboxylic acid, and friends who are interested can also refer to it.<\/p>\n

Reference:
Patent; GLAXO GROUP LIMITED; WO2009\/147188; (2009); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Methyl-1H-pyrazole-3-carboxylic acid, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[159,131],"tags":[126],"class_list":["post-4013","post","type-post","status-publish","format-standard","hentry","category-402-61-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nDiscovery of 5-Methyl-1H-pyrazole-3-carboxylic acid<\/title>\n<meta name=\"description\" content=\"Reference of 402-61-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 402-61-9 name is 5-Methyl-1H-pyrazole-3-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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