{"id":4009,"date":"2021-04-26T00:00:00","date_gmt":"2021-04-25T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4009"},"modified":"2021-04-26T00:00:00","modified_gmt":"2021-04-25T16:00:00","slug":"the-origin-of-a-common-compound-about-4-iodo-1-tetrahydropyran-2-yl-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4009","title":{"rendered":"The origin of a common compound about 4-Iodo-1-(tetrahydropyran-2-yl)-1H-pyrazole"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 938066-17-2, name is 4-Iodo-1-(tetrahydropyran-2-yl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-Iodo-1-(tetrahydropyran-2-yl)-1H-pyrazole<\/a><\/p>\n

lodopyrazole (153 g, 550 mmol, 1.1 equiv.) was dissolved in THF (2 L) under N2 and the solution was cooled in an ice-water bath. i-PrMgC1 (2 M in THF, 300 mL, 600 mmol,1.2 equiv.) was added dropwise with vigorous stirring. After 60 minutes, solid benzoxazinonesubstrate was added, and the ice bath was removed. After 45 minutes, 10% aqueous NaOH (720mL, 2 mol, 4 equiv.) was added, and the mixture was heated to 65 C. After five hours, thereaction mixture was cooled to room temperature, quenched with 10% aqueous HC1 (690 mL, 2 mol, 4 equiv.), and extracted with EtOAc. The combined organic extracts were dried and concentrated to afford a viscous yellow\/orange oil that was used without further purification.<\/p>\n

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 938066-17-2.<\/p>\n

Reference:
Patent; ARCUS BIOSCIENCES, INC.; LELETI, Manmohan, Reddy; MILES, Dillon, Harding; POWERS, Jay, Patrick; ROSEN, Brandon, Reid; SHARIF, Ehesan, Ul; THOMAS-TRAN, Rhiannon; (154 pag.)WO2018\/204661; (2018); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 938066-17-2.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[625,131],"tags":[127],"class_list":["post-4009","post","type-post","status-publish","format-standard","hentry","category-938066-17-2","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nThe origin of a common compound about 4-Iodo-1-(tetrahydropyran-2-yl)-1H-pyrazole<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 938066-17-2, name is 4-Iodo-1-(tetrahydropyran-2-yl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-Iodo-1-(tetrahydropyran-2-yl)-1H-pyrazole\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4009\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The origin of a common compound about 4-Iodo-1-(tetrahydropyran-2-yl)-1H-pyrazole\" \/>\n<meta property=\"og:description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 938066-17-2, name is 4-Iodo-1-(tetrahydropyran-2-yl)-1H-pyrazole, This compound has unique chemical properties. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The origin of a common compound about 4-Iodo-1-(tetrahydropyran-2-yl)-1H-pyrazole","description":"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 938066-17-2, name is 4-Iodo-1-(tetrahydropyran-2-yl)-1H-pyrazole, This compound has unique chemical properties. 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