{"id":4005,"date":"2021-04-26T00:00:00","date_gmt":"2021-04-25T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4005"},"modified":"2021-04-26T00:00:00","modified_gmt":"2021-04-25T16:00:00","slug":"continuously-updated-synthesis-method-about-135-trimethyl-1h-pyrazol-4-amine","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4005","title":{"rendered":"Continuously updated synthesis method about 1,3,5-Trimethyl-1H-pyrazol-4-amine"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 28466-21-9, name is 1,3,5-Trimethyl-1H-pyrazol-4-amine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H11N3<\/a><\/p>\n

Reference Example 37 Ethyl 4-{4-chloro-7-(1-ethylpropyl)-2-[(1,3,5-trimethyl-1H-pyrazol-4-yl)amino]-1H-benzimidazol-1-yl}butanoate A mixture of ethyl 4-[2,4-dichloro-7-(1-ethylpropyl)-1H-benzimidazol-1-yl]butanoate (Reference Example 33; 371 mg, 1.00 mmol), 4-amino-1,3,5-trimethylpyrazole (375 mg, 3.00 mmol) and p-toluenesulfonic acid monohydrate (190 mg, 1.00 mmol) in 1-methyl-2-pyrrolidinone (3 mL) was stirred at 150 C. for 16 hr. After cooling, aqueous sodium bicarbonate was added and the mixture was extracted with ethyl acetate. Organic layer was washed with water and brine, dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was purified by flash chromatography on silica gel eluding with a 0-5% methanol\/ethyl acetate gradient mixture. The filtrate was concentrated in vacuo to give the solid, which was recrystallized from ethyl acetate\/n-hexane to give the title compound (340 mg, 0.74 mmol, 74%) as a colorless solid. mp 177-178 C. 1H NMR (CDCl3) delta 0.86 (t, J=7.3 Hz, 6H), 1.28 (t, J=7.0 Hz, 3H), 1.64-1.85 (m, 4H), 2.03-2.16 (m, 2H), 2.20 (s, 3H), 2.22 (s, 3H), 2.44-2.51 (m, 2H), 2.87-2.99 (m, 1H), 3.74 (s, 3H), 4.10-4.24 (m, 4H), 6.79 (d, J=8.3 Hz, 1H), 6.90 (s, 1H), 7.08 (d, J=8.3 Hz, 1H). MS Calcd.: 459; Found: 460 (M+H).<\/p>\n

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 28466-21-9.<\/p>\n

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; US2009\/186879; (2009); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 28466-21-9.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[624,131],"tags":[126],"class_list":["post-4005","post","type-post","status-publish","format-standard","hentry","category-28466-21-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nContinuously updated synthesis method about 1,3,5-Trimethyl-1H-pyrazol-4-amine<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 28466-21-9, name is 1,3,5-Trimethyl-1H-pyrazol-4-amine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H11N3\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4005\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Continuously updated synthesis method about 1,3,5-Trimethyl-1H-pyrazol-4-amine\" \/>\n<meta property=\"og:description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 28466-21-9, name is 1,3,5-Trimethyl-1H-pyrazol-4-amine, This compound has unique chemical properties. 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