{"id":4003,"date":"2021-04-26T00:00:00","date_gmt":"2021-04-25T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4003"},"modified":"2021-04-26T00:00:00","modified_gmt":"2021-04-25T16:00:00","slug":"analyzing-the-synthesis-route-of-1h-pyrazol-4-ylmethanol","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4003","title":{"rendered":"Analyzing the synthesis route of (1H-Pyrazol-4-yl)methanol"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25222-43-9, SDS of cas: 25222-43-9<\/a><\/p>\n

General procedure: Add acid chloride (2mmol) dropwise to (1H-pyrazol-4-yl) methanol or(1H-3,5-dimethylpyrazol-4-yl) methanol (1 mmol),4-Dimethylaminopyridine (0.2mmol) and triethylamine (2.5mmol) were dissolved in a solution of dichloromethane (30mL), and the reaction was stirred at room temperature for 12 hours, and then a saturated sodium bicarbonate solution was slowly added with sufficient stirring. Until the reaction no longer produces gas,The layers were separated, and the organic phase was washed twice with saturated sodium bicarbonate solution (20 mL each time) and once with water (20 mL). The organic phase was dried over anhydrous sodium sulfate and the solvent was removed by rotary evaporation. The residue was purified on a silica gel column of 100-200 mesh, and ethyl acetate \/ petroleum ether (60-90 C) (1: 5, volume ratio) was used as eluent. After removing the solvent by rotary evaporation, a pyrazole methoxide derivative having the general chemical structure I is obtained.<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1H-Pyrazol-4-yl)methanol, other downstream synthetic routes, hurry up and to see.<\/p>\n

Reference:
Patent; Nankai University; Tang Liangfu; Xu Yue; Yang Jiali; Xia Dongqi; (10 pag.)CN110386899; (2019); A;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1H-Pyrazol-4-yl)methanol, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[146,131],"tags":[145],"class_list":["post-4003","post","type-post","status-publish","format-standard","hentry","category-25222-43-9","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nAnalyzing the synthesis route of (1H-Pyrazol-4-yl)methanol<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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