{"id":4002,"date":"2021-04-26T00:00:00","date_gmt":"2021-04-25T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4002"},"modified":"2021-04-26T00:00:00","modified_gmt":"2021-04-25T16:00:00","slug":"the-important-role-of-345-tribromopyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4002","title":{"rendered":"The important role of 3,4,5-Tribromopyrazole"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17635-44-8, name is 3,4,5-Tribromopyrazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 3,4,5-Tribromopyrazole<\/a><\/p>\n

To a solution of 3,4,5-tribromo-lH-pyrazole (25 g, 82 mmol, 1.0 eq) in THF (300 ml), was added n-BuLi (2.5 M in hexanes, 82.0 ml, 205 mmol, 2.5 eq) over 30 min at -78C and the RM was stirred at this temperature for 1.5 h. The RM was quenched by dropwise addition of MeOH-THF (2:3; 150 ml) at -78C, stirred for an additional 2 h gradually allowing it to warm to RT. Then, the solvent was removed under reduced pressure. The residue was diluted with diethyl ether (600 ml), washed with dil. HC1 (0.5 N, 60 ml) and brine (75 ml), dried (Na2S04), filtered and concentrated under reduced pressure to afford the title compound (18 g).<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n

Reference:
Patent; GRUeNENTHAL GMBH; SCHUNK, Stephan; REICH, Melanie; KOENIGS, Rene, Michael; (72 pag.)WO2017\/59966; (2017); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[190,131],"tags":[167],"class_list":["post-4002","post","type-post","status-publish","format-standard","hentry","category-17635-44-8","category-pyrazoles-derivatives","tag-m-w300-400"],"yoast_head":"\nThe important role of 3,4,5-Tribromopyrazole<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17635-44-8, name is 3,4,5-Tribromopyrazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 3,4,5-Tribromopyrazole\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4002\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of 3,4,5-Tribromopyrazole\" \/>\n<meta property=\"og:description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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