{"id":4000,"date":"2021-04-26T00:00:00","date_gmt":"2021-04-25T16:00:00","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4000"},"modified":"2021-04-26T00:00:00","modified_gmt":"2021-04-25T16:00:00","slug":"discovery-of-5-chloro-1h-pyrazole-3-carboxylic-acid","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4000","title":{"rendered":"Discovery of 5-Chloro-1H-pyrazole-3-carboxylic acid"},"content":{"rendered":"

Related Products of 881668-70-8<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 881668-70-8 as follows.<\/p>\n

4,5-Dichloropyrazole-3-carboxyh’c acid (TV”)Chlorine gas was bubbled slowly through a stirred solution of 5-chloropyrazole-3- carboxylic acid (Intermediate II, 3.00 g, 20.5 mmol) in water (2.0 L) at rt over 3 h. The solution was stirred for 18 h in an open flask and then concentrated in vacuo. The slurry was extracted with ethyl acetate (3×100 mL), the combined extracts were washed with NaCl (sat., aq.; 100 mL) and dried (Na2SO4). The solvent was removed in vacuo to give the product as a white powder. Yield 3.20 g (86 %). MS (MT-H) Wk= 179. 1H NMR (DMSO^6, 400 MHz) delta 14.44 (s, IH), 14.09 (s, IH). 13CNMR (CD3OD, 100 MHz) delta 160.0; 139.6; 133.1; 112.4.<\/p>\n

According to the analysis of related databases, 881668-70-8, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; BIOLIPOX AB; WO2007\/51981; (2007); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 881668-70-8, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[623,131],"tags":[126],"class_list":["post-4000","post","type-post","status-publish","format-standard","hentry","category-881668-70-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nDiscovery of 5-Chloro-1H-pyrazole-3-carboxylic acid<\/title>\n<meta name=\"description\" content=\"Related Products of 881668-70-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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