{"id":3958,"date":"2021-05-11T03:58:18","date_gmt":"2021-05-10T19:58:18","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3958"},"modified":"2021-05-11T03:58:18","modified_gmt":"2021-05-10T19:58:18","slug":"application-of-128694-63-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3958","title":{"rendered":"Application of 128694-63-3"},"content":{"rendered":"

Synthetic Route of 128694-63-3<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 128694-63-3 as follows.<\/p>\n

Example 310 Production of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-fluorophenyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide In the same manner as in Example 259 and using 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid (150 mg, 0.79 mmol), tetrahydrofuran (5 mL), N,N-dimethylformamide (1 drop), oxalyl chloride (140 muL, 1.6 mmol), N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide (200 mg, 0.61 mmol) and N,N-dimethylacetamide (7 mL) as starting materials, the title compound (240 mg, 77%) was obtained as a white solid. 1H-NMR (DMSO-d6, 300 MHz) delta 0.71-0.85 (4H, m), 1.85-1.97 (1H, m), 4.15 (3H, s), 7.09 (1H, d, J=9.4 Hz), 7.21-7.28 (1H, m), 7.39-7.47 (1H, m), 7.54 (1H, s), 7.58 (1H, dd, J=6.3, 2.9 Hz), 7.95 (1H, s), 8.05 (1H, d, J=9.4 Hz), 10.45 (1H, s), 11.08 (1H, s).<\/p>\n

According to the analysis of related databases, 128694-63-3, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 128694-63-3, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[608,131],"tags":[126],"class_list":["post-3958","post","type-post","status-publish","format-standard","hentry","category-128694-63-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nApplication of 128694-63-3<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 128694-63-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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