{"id":3936,"date":"2021-05-11T03:57:25","date_gmt":"2021-05-10T19:57:25","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3936"},"modified":"2021-05-11T03:57:25","modified_gmt":"2021-05-10T19:57:25","slug":"sources-of-common-compounds-25700-12-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3936","title":{"rendered":"Sources of common compounds: 25700-12-3"},"content":{"rendered":"

25700-12-3, name is 3-(1H-Pyrazol-1-yl)pyridine, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 3-(1H-Pyrazol-1-yl)pyridine<\/a><\/p>\n

Step 1: 3-(4-Bromopyrazol-1-yl)pyridine 3-Pyrazol-1-ylpyridine (500 mg, 3.44 mmol) was dissolved in acetonitrile (15 ml), and ammonium cerium(IV) nitrate (944 mg, 1.72 mmol) was added (slightly exothermic). N-Bromosuccinimide (736 mg, 4.13 mmol) was added a little at a time (slightly exothermic) and the mixture was stirred at room temperature for 30 min and then heated under reflux for 3 hours (h). After the mixture had cooled, ethyl acetate was added. The organic phase was washed with water, washed with a sodium sulphate solution and then dried with magnesium sulphate. The solvent was removed under reduced pressure using a rotary evaporator. Yield: 750 mg (93% of theory), logP(HCOOH) 1.56, [M++1] 224.0 1H-NMR (d6-DMSO): 7.54 (m, 1H), 7.90 (s, 1H), 8.20 (m, 1H), 8.55 (m, 1H), 8.79 (s, 1H), 9.06 (m, 1H).<\/p>\n

The synthetic route of 25700-12-3 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 25700-12-3 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[606,131],"tags":[126],"class_list":["post-3936","post","type-post","status-publish","format-standard","hentry","category-25700-12-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSources of common compounds: 25700-12-3<\/title>\n<meta name=\"description\" content=\"25700-12-3, name is 3-(1H-Pyrazol-1-yl)pyridine, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. 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