{"id":3935,"date":"2021-05-11T03:57:25","date_gmt":"2021-05-10T19:57:25","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3935"},"modified":"2021-05-11T03:57:25","modified_gmt":"2021-05-10T19:57:25","slug":"some-scientific-research-about-1-2-chloroethyl-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3935","title":{"rendered":"Some scientific research about 1-(2-Chloroethyl)-1H-pyrazole"},"content":{"rendered":"

Some common heterocyclic compound, 96450-53-2, name is 1-(2-Chloroethyl)-1H-pyrazole, molecular formula is C5H7ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-(2-Chloroethyl)-1H-pyrazole<\/a><\/p>\n

A mixture of 13.02 g (0.1 mol) of 1-(2-chloroethyl)pyrazole 1, 11.2 g (0.2 mol) of KOH, and 50 mL of 50 wt% aqueous solution of MMO was vigorously stirred during 2 h at 80C. After cooling to ambient, the reaction mixture was extracted with chloroform. The solvent was removed, and the residue was distilled in vacuum. Yield 7.0 g (75%), bp 63C(50 mmHg), nD20 1.5160 [16]. IR spectrum, nu, cm-1:1520 (ring), 1640 (C=C). 1H NMR spectrum, delta, ppm(J, Hz): 5.00 d.d (1H, =CH2, J = 9.0, 1.5), 5.52 d.d(1H, =CH2, J = 15.8, 1.5), 6.26 t (1H, 4-H, J = 2.2),7.12 d.d (1H, NC=H, J = 15.8, 9.0), 7.50 d (1H, 3-H,J = 2.4), 7.58 d (1H, 5-H, J = 2.0).<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 96450-53-2, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 96450-53-2, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[605,131],"tags":[126],"class_list":["post-3935","post","type-post","status-publish","format-standard","hentry","category-96450-53-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSome scientific research about 1-(2-Chloroethyl)-1H-pyrazole<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 96450-53-2, name is 1-(2-Chloroethyl)-1H-pyrazole, molecular formula is C5H7ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-(2-Chloroethyl)-1H-pyrazole\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3935\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Some scientific research about 1-(2-Chloroethyl)-1H-pyrazole\" \/>\n<meta property=\"og:description\" content=\"Some common heterocyclic compound, 96450-53-2, name is 1-(2-Chloroethyl)-1H-pyrazole, molecular formula is C5H7ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-(2-Chloroethyl)-1H-pyrazole\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3935\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-10T19:57:25+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3935\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3935\",\"name\":\"Some scientific research about 1-(2-Chloroethyl)-1H-pyrazole\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-05-10T19:57:25+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Some common heterocyclic compound, 96450-53-2, name is 1-(2-Chloroethyl)-1H-pyrazole, molecular formula is C5H7ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-(2-Chloroethyl)-1H-pyrazole\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3935#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=3935\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3935#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Some scientific research about 1-(2-Chloroethyl)-1H-pyrazole\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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