{"id":3931,"date":"2021-05-11T03:57:25","date_gmt":"2021-05-10T19:57:25","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3931"},"modified":"2021-05-11T03:57:25","modified_gmt":"2021-05-10T19:57:25","slug":"the-important-role-of-1h-pyrazol-4-amine-hydrochloride","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3931","title":{"rendered":"The important role of 1H-Pyrazol-4-amine hydrochloride"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4331-28-6, name is 1H-Pyrazol-4-amine hydrochloride, A new synthetic method of this compound is introduced below., category: pyrazoles-derivatives<\/a><\/p>\n

To a mixture of (R)-2-(methylcarbamoyl)-6-(1-phenylethyl)isonicotinic acid (53.7 mg, 0.19 mmol),HATU (86.7 mg, 0.23 mmol) and 1H-pyrazol-4-amine, hydrochloride (28.9 mg, 0.24 mmol) in DMF (1mL) was added DIPEA (0.132 mL, 0.76 mmol). The resulting dark grey solution was stirred at rt for2.75 h. The reaction mixture was diluted with DMSO (2 mL) and directly purified by MDAP (3 mLinjection, high pH). The required fractions (fractions 1 and 2) were combined and evaporated in vacuoto give the desired product as a light yellow solid – (R)-N2-methyl-6-(1-phenylethyl)-N4-(1H-pyrazol-4-yl)pyridine-2,4-dicarboxamide (39.9 mg, 0.11 mmol, 61 % yield)LCMS (2 mm High pH): Rt = 0.92 mi [MH]+ = 350.3.<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[601,131],"tags":[126],"class_list":["post-3931","post","type-post","status-publish","format-standard","hentry","category-4331-28-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 1H-Pyrazol-4-amine hydrochloride<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4331-28-6, name is 1H-Pyrazol-4-amine hydrochloride, A new synthetic method of this compound is introduced below., category: pyrazoles-derivatives\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3931\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of 1H-Pyrazol-4-amine hydrochloride\" \/>\n<meta property=\"og:description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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