{"id":3925,"date":"2021-05-10T04:38:55","date_gmt":"2021-05-09T20:38:55","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3925"},"modified":"2021-05-10T04:38:55","modified_gmt":"2021-05-09T20:38:55","slug":"new-learning-discoveries-about-3-25-dimethyl-1h-pyrrol-1-yl-1-methyl-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3925","title":{"rendered":"New learning discoveries about 3-(2,5-Dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 34605-66-8 as follows. Recommanded Product: 34605-66-8<\/a><\/p>\n

To a solution of 3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole (6.4 g) in tetrahydrofuran (70 mL) was added dropwise n-butyllithium (1.6 M hexane solution, 27 mL) at -78 C., and the mixture was stirred at the same temperature for 1 hr. To the reaction mixture was added dropwise di-tert-butyl dicarbonate (11 mL) at -78 C., and the mixture was stirred for 2 hr while gradually raising the temperature to room temperature. To the reaction mixture was added saturated aqueous ammonium chloride solution, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane\/ethyl acetate) to give the title compound (7.9 g). 1H NMR (400 MHz, DMSO-d6) delta1.56 (9H, s), 1.94-2.13 (6H, m), 4.09 (3H, s), 5.77 (2H, s), 6.84 (1H, s). MS(ESI+): [M+H]+ 276.1.<\/p>\n

According to the analysis of related databases, 34605-66-8, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 34605-66-8, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[269,131],"tags":[126],"class_list":["post-3925","post","type-post","status-publish","format-standard","hentry","category-34605-66-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nNew learning discoveries about 3-(2,5-Dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 34605-66-8 as follows. 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