{"id":3920,"date":"2021-05-10T04:38:55","date_gmt":"2021-05-09T20:38:55","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3920"},"modified":"2021-05-10T04:38:55","modified_gmt":"2021-05-09T20:38:55","slug":"introduction-of-a-new-synthetic-route-about-nn-dimethyl-1h-pyrazole-1-sulfonamide","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3920","title":{"rendered":"Introduction of a new synthetic route about N,N-Dimethyl-1H-pyrazole-1-sulfonamide"},"content":{"rendered":"

Reference of 133228-21-4<\/a>, The chemical industry reduces the impact on the environment during synthesis 133228-21-4, name is N,N-Dimethyl-1H-pyrazole-1-sulfonamide, I believe this compound will play a more active role in future production and life.<\/p>\n

To a solution of N,N-dimethylsulfamoylpyrazole (44.0 g, 0.251 mol) in dry tetrahydrofuran (500 ml) at -78C was added dropwise a solution of n-butyllithium (2.5 M in hexane, 105.5 ml, 0.264 mol) while maintaining the temperature below -60C. A thick solid formed during the addition. Upon completion of the addition the reaction mixture was maintained for an additional 15 minutes, after which time a solution of 1,2-dibromotetrachloroethane (90 g, 0.276 mol) in tetrahydrofuran (150 ml) was added dropwise while maintaining the temperature below -70C. The reaction mixture turned a clear orange; stirring was continued for an additional 15 minutes. The -78C bath was removed and the reaction was quenched with water (600 ml). The reaction mixture was extracted with methylene chloride (4x), and the organic extracts were dried over magnesium sulfate and concentrated. The crude product was further purified by chromatography on silica gel using methylene chloride-hexane (50 : 50) as eluent to afford 57.04 g of the title product as clear colorless oil. 1H NMR (CDCl3): delta 3.07 (d, 6H), 6.44 (m, 1H), 7.62 (m, 1H).<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N,N-Dimethyl-1H-pyrazole-1-sulfonamide, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N,N-Dimethyl-1H-pyrazole-1-sulfonamide, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[309,131],"tags":[126],"class_list":["post-3920","post","type-post","status-publish","format-standard","hentry","category-133228-21-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nIntroduction of a new synthetic route about N,N-Dimethyl-1H-pyrazole-1-sulfonamide<\/title>\n<meta name=\"description\" content=\"Reference of 133228-21-4, The chemical industry reduces the impact on the environment during synthesis 133228-21-4, name is N,N-Dimethyl-1H-pyrazole-1-sulfonamide, I believe this compound will play a more active role in future production and life.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3920\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Introduction of a new synthetic route about N,N-Dimethyl-1H-pyrazole-1-sulfonamide\" \/>\n<meta property=\"og:description\" content=\"Reference of 133228-21-4, The chemical industry reduces the impact on the environment during synthesis 133228-21-4, name is N,N-Dimethyl-1H-pyrazole-1-sulfonamide, I believe this compound will play a more active role in future production and life.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=3920\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-09T20:38:55+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3920\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3920\",\"name\":\"Introduction of a new synthetic route about N,N-Dimethyl-1H-pyrazole-1-sulfonamide\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-05-09T20:38:55+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Reference of 133228-21-4, The chemical industry reduces the impact on the environment during synthesis 133228-21-4, name is N,N-Dimethyl-1H-pyrazole-1-sulfonamide, I believe this compound will play a more active role in future production and life.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3920#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=3920\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=3920#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Introduction of a new synthetic route about N,N-Dimethyl-1H-pyrazole-1-sulfonamide\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Introduction of a new synthetic route about N,N-Dimethyl-1H-pyrazole-1-sulfonamide","description":"Reference of 133228-21-4, The chemical industry reduces the impact on the environment during synthesis 133228-21-4, name is N,N-Dimethyl-1H-pyrazole-1-sulfonamide, I believe this compound will play a more active role in future production and life.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=3920","og_locale":"en_US","og_type":"article","og_title":"Introduction of a new synthetic route about N,N-Dimethyl-1H-pyrazole-1-sulfonamide","og_description":"Reference of 133228-21-4, The chemical industry reduces the impact on the environment during synthesis 133228-21-4, name is N,N-Dimethyl-1H-pyrazole-1-sulfonamide, I believe this compound will play a more active role in future production and life.","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=3920","og_site_name":"pyrazoles-derivatives","article_published_time":"2021-05-09T20:38:55+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=3920","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=3920","name":"Introduction of a new synthetic route about N,N-Dimethyl-1H-pyrazole-1-sulfonamide","isPartOf":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2021-05-09T20:38:55+00:00","author":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Reference of 133228-21-4, The chemical industry reduces the impact on the environment during synthesis 133228-21-4, name is N,N-Dimethyl-1H-pyrazole-1-sulfonamide, I believe this compound will play a more active role in future production and life.","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=3920#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=3920"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=3920#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"http:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Introduction of a new synthetic route about N,N-Dimethyl-1H-pyrazole-1-sulfonamide"}]},{"@type":"WebSite","@id":"http:\/\/www.pyrazoles-derivatives.com\/#website","url":"http:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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