{"id":3916,"date":"2021-05-10T04:38:08","date_gmt":"2021-05-09T20:38:08","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3916"},"modified":"2021-05-10T04:38:08","modified_gmt":"2021-05-09T20:38:08","slug":"a-new-synthetic-route-of-ethyl-4-pyrazolecarboxylate","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3916","title":{"rendered":"A new synthetic route of Ethyl 4-pyrazolecarboxylate"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of Ethyl 4-pyrazolecarboxylate<\/a><\/p>\n

To a suspension of LAH (45.2 mL, 45.2 mmol, 1M in THF) in a flame-driedRBF was added a solution of ethyl 1H-pyrazole-4-carboxylate (3.17 g, 22.6 mmol) inTHF (20 mL) dropwise at 0 \u00b0C. The reaction was gradually warmed up to rt and stirred atrt overnight. The reaction mixture was cooled in an ice bath and carefully quenched bysequential dropwise addition of 1.36 mL H20, and 10 mL of 1MNaOH, then stirred 20 mm. Solid Mg504 was added, the ice bath was removed, and stirring was continued for 30 mm at room temp. Solids were removed by filtration through CELITE\u00ae and washed with THF, then MeOH. The combined filtrate was evaporated to give (1H-pyrazol-4-yl)methanol (1.75 g, 78.9percent), as a white solid. ?HNMR(500MF-Tz, DMSO-d6)oe 12.58(br. s., 1H), 7.58 (s, 1H), 7.40 (s, 1H), 4.74 (t, J=5.5 Hz, 1H), 4.37 (d, J=5.2 Hz, 2H).<\/p>\n

According to the analysis of related databases, 37622-90-5, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 37622-90-5, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[218,131],"tags":[126],"class_list":["post-3916","post","type-post","status-publish","format-standard","hentry","category-37622-90-5","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nA new synthetic route of Ethyl 4-pyrazolecarboxylate<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, This compound has unique chemical properties. 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