{"id":3902,"date":"2021-05-10T04:38:08","date_gmt":"2021-05-09T20:38:08","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=3902"},"modified":"2021-05-10T04:38:08","modified_gmt":"2021-05-09T20:38:08","slug":"simple-exploration-of-tert-butyl-tert-butoxycarbonylamino1h-pyrazol-1-ylmethylenecarbamate","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=3902","title":{"rendered":"Simple exploration of tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate"},"content":{"rendered":"

152120-54-2, name is tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate<\/a><\/p>\n

Synthesis of N-Boc-N’-n-octyl-1-guanylpyrazole (0288) Under ice-cooling and under nitrogen atmosphere, to a suspension of NaH (60% in oil, 283 mg, 7.08 mmol) in DMF (10 mL)) was added N,N’-bis-Boc-1-guanylpyrazole (2 g, 6.44 mmol) by small portions. After stirring at the same temperature for 15 min, 1-iodooctane (2.33 mL, 12.9 mmol) was added dropwise, and the mixture was stirred overnight while raising the temperature to room temperature. Under ice-cooling, water was added to discontinue the reaction, and the whole mixture was extracted with AcOEt. The organic layer was washed with saturated aqueous NaCl solution, and dried over MgSO4 and concentrated under reduced pressure. The residue was purified by silica gel chromatography using n-hexane:AcOEt = 8:1 as an eluate to give the object product as an oil (yield: 1.8 g, 66.1%). 1H NMR(300 MHz, CHLOROFORM-d)deltappm 0.78 – 0.92 (3 H, m), 1.19 – 1.36 (10 H, m), 1.27 (9 H, s), 1.50 (9 H, s), 1.65 – 1.81 (2 H, m), 3.61 – 3.69 (2 H, m), 6.41 (1 H, dd, J=2.7, 1.6 Hz), 7.69 (1 H, d, J=1.1 Hz), 7.93 (1 H, br. s.)<\/p>\n

The synthetic route of 152120-54-2 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 152120-54-2 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[254,131],"tags":[167],"class_list":["post-3902","post","type-post","status-publish","format-standard","hentry","category-152120-54-2","category-pyrazoles-derivatives","tag-m-w300-400"],"yoast_head":"\nSimple exploration of tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate<\/title>\n<meta name=\"description\" content=\"152120-54-2, name is tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=3902\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Simple exploration of tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate\" \/>\n<meta property=\"og:description\" content=\"152120-54-2, name is tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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The chemical synthesis route is as follows. 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The chemical synthesis route is as follows. Quality Control of tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"http:\/\/www.pyrazoles-derivatives.com\/?p=3902","og_locale":"en_US","og_type":"article","og_title":"Simple exploration of tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate","og_description":"152120-54-2, name is tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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